rs2596542, MICA-AS1;MICA

N. diseases: 18
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC. 30882647 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively. 24357186 2014
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population. 23994040 2013
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.100 GeneticVariation BEFREE A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population. 23994040 2013
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.100 GeneticVariation BEFREE An extended region around rs2596542 was genotyped in 1924 HCV-infected patients from the Swiss Hepatitis C Cohort Study (SCCS). 23665287 2013
Hepatitis C, Chronic
CUI: C0524910
Disease: Hepatitis C, Chronic
0.020 GeneticVariation BEFREE Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients. 31471884 2019
Hepatitis C Virus-Related Hepatocellular Carcinoma
0.010 GeneticVariation BEFREE Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases. 28417047 2017
AIDS, PROGRESSION TO
CUI: C1836233
Disease: AIDS, PROGRESSION TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
HIV-1, RESISTANCE TO
CUI: C1836231
Disease: HIV-1, RESISTANCE TO
0.700 GeneticVariation GWASDB Common genetic variation and the control of HIV-1 in humans. 20041166 2009
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC. 26893439 2016
Liver Cirrhosis
CUI: C0023890
Disease: Liver Cirrhosis
0.030 GeneticVariation BEFREE Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC. 29584564 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC. 29584564 2018
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development. 27998720 2017
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASDB Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma. 23242368 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma. 28427234 2017
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.010 GeneticVariation BEFREE Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients. 23994040 2013
Hepatitis B Virus-Related Hepatocellular Carcinoma
0.010 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population. 24204805 2013
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.100 GeneticVariation BEFREE Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population. 24204805 2013
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASCAT Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation GWASDB Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma. 21499248 2011
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039). 31471884 2019
Liver carcinoma
CUI: C2239176
Disease: Liver carcinoma
0.900 GeneticVariation BEFREE In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150). 26517016 2016
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.100 GeneticVariation BEFREE In summary, the MICA rs2596538 and rs2596542 variants warrant further research for their clinical validity and utility in relationship to the risk of developing HCV-related HCC in independent populations. 29584564 2018