Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A meta-analysis was performed to examine the association between MICA rs2596542 polymorphism and susceptibility to HCC.
|
30882647 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A moderate increase in differentiation was noted for rs2596542 (F st = 0.106) and rs17401966 (F st = 0.116), single nucleotide polymorphisms (SNPs) associated with an increased risk of HCC in patients with chronic HCV and HBV, respectively.
|
24357186 |
2014 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
A recent genome-wide association study has identified a single nucleotide polymorphism (SNP) of MICA, rs2596542 to be significantly associated with hepatitis C-induced hepatocellular carcinoma (HCC) in a Japanese population.
|
23994040 |
2013 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
An extended region around rs2596542 was genotyped in 1924 HCV-infected patients from the Swiss Hepatitis C Cohort Study (SCCS).
|
23665287 |
2013 |
Hepatitis C, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients.
|
31471884 |
2019 |
Hepatitis C Virus-Related Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases.
|
28417047 |
2017 |
AIDS, PROGRESSION TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
ACQUIRED IMMUNODEFICIENCY SYNDROME, PROGRESSION TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
HIV-1, RESISTANCE TO
|
|
0.700 |
GeneticVariation
|
GWASDB |
Common genetic variation and the control of HIV-1 in humans.
|
20041166 |
2009 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
CONCLUSIONS IFN-γ rs2069727 and MICA rs2596542 polymorphisms may be related to the incidence of HCC.
|
26893439 |
2016 |
Liver Cirrhosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
For cirrhotic non-SVR patients, high sMICA levels (HR/CI: 5·93/1·86–26·38, P = 0·002) [corrected] and the MICA rs2596542 A allele (HR/CI: 4·37/1·52–12·07, P = 0·002) were independently associated with HCC development.
|
27998720 |
2017 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
Genetic variants of MHC class I polypeptide-related chain A (MICA) at rs2596542 have been associated with hepatocellular carcinoma.
|
28427234 |
2017 |
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients.
|
23994040 |
2013 |
Hepatitis B Virus-Related Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
GWASDB |
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.
|
21499248 |
2011 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, genotype frequencies of rs2596542A/G SNP were statistically different between HCV-induced HCC patients and controls (p = 0.048), and also between HCC and HCV-induced cirrhosis patients (p = 0.039).
|
31471884 |
2019 |
Liver carcinoma
|
|
0.900 |
GeneticVariation
|
BEFREE |
In a Northern Italian discovery cohort (n = 477), neither DEPDC5 rs1012068 nor MICA rs2596542 were associated with HCC (n = 150).
|
26517016 |
2016 |
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, the MICA rs2596538 and rs2596542 variants warrant further research for their clinical validity and utility in relationship to the risk of developing HCV-related HCC in independent populations.
|
29584564 |
2018 |