|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation
|
BEFREE |
TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040-1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101-1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002-1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172-1.936, P = 0.001).
|
31419949 |
2019 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
Patients with the SNP rs2596542 A allele had significantly lower MICA expression in tumor tissue than did those with the GG genotype (24.7 ± 15.1% vs. 41.5 ± 23.4%, P < 0.001).
|
30361527 |
2018 |
|
Liver diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, SNP (rs2596542C/T) in MICA promoter region and sMICA levels might be potential useful markers in the assessment of liver disease progression to LC and HCC.
|
28417047 |
2017 |
|
Hepatitis C Virus-Related Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases.
|
28417047 |
2017 |
|
Fibrosis, Liver
|
|
0.010 |
GeneticVariation
|
BEFREE |
Serum level and single nucleotide polymorphism at rs2596542 of MICA were tested for the association with liver fibrosis in 319 biopsy proven chronic hepatitis C patients.
|
28427234 |
2017 |
|
Hepatitis B Virus-Related Hepatocellular Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |
|
Hepatitis B, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic variation at -1878 (rs2596542) in MICA gene region is associated with chronic hepatitis B virus infection in Saudi Arabian patients.
|
23994040 |
2013 |
|
Cirrhosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC.
|
23994040 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040-1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101-1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002-1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172-1.936, P = 0.001).
|
31419949 |
2019 |
|
Hepatitis C, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Association between MICA rs2596542 Polymorphism with the Risk of Hepatocellular Carcinoma in Chronic Hepatitis C Patients.
|
31471884 |
2019 |
|
Hepatocarcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
|
Hepatitis C, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040-1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101-1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002-1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172-1.936, P = 0.001).
|
31419949 |
2019 |
|
Hepatocarcinogenesis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The C allele in MICA rs2596542 is a protective factor for hepatocarcinogenesis, whereas the T allele is a risk factor.
|
30882647 |
2019 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TT genotype was found to occur more frequently among active HBV carriers (groups II, III and IV) when compared to inactive HBV carriers, thus suggesting that the rs2596542-T may be recessively associated with an active HBV infection.
|
23994040 |
2013 |
|
Liver Cirrhosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Finally, sMICA levels significantly increased during HCV-related liver disease progression, while a significant relationship between both rs2596542 and rs2596538 genotypes and sMICA plasma levels was identified in patients with LC and HCC.
|
29584564 |
2018 |
|
Liver Cirrhosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Studying SNP rs2596542C/T association with HCC and LC susceptibility revealed that statistical significant differences (<i>P</i> = 0.013, <i>P</i> = 0.027) were only observed between SNP rs2596542C/T and each of HCC and LC, respectively, versus healthy controls, indicating that the rs2596542C/T genetic variation is not a significant contributor to HCC development in LC patients.
|
28417047 |
2017 |
|
Liver Cirrhosis
|
|
0.030 |
GeneticVariation
|
BEFREE |
Therefore, this study aims to investigate whether the SNP rs2596542 plays any role in hepatitis B virus (HBV) sero-clearance or in the development of complications associated with chronic HBV such as cirrhosis and/or HCC.
|
23994040 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
TT genotype at rs2596542 was a risk factor for the development of HCC in patients with HCV/HBV infection (OR = 1.248, 95% CI: 1.040-1.499, P = 0.017), particularly those with HCV infection (OR = 1.326, 95% CI: 1.101-1.599, P = 0.003) and Asians (OR = 1.273, 95% CI: 1.002-1.618, P = 0.048), or when the control group was patients with chronic hepatitis C (CHC) (OR = 1.506, 95% CI: 1.172-1.936, P = 0.001).
|
31419949 |
2019 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Taken together our study suggest that MICA rs2596542 SNP impacts HCV-induced HCC susceptibility suggesting that genetic variants in MICA are of clinical relevance to hepatocarcinogenesis by impacting host immune response in chronic HCV infection.
|
31471884 |
2019 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
In summary, the MICA rs2596538 and rs2596542 variants warrant further research for their clinical validity and utility in relationship to the risk of developing HCV-related HCC in independent populations.
|
29584564 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
We enrolled 787 consecutive patients with chronic HCV infection, which included 174 cases of HCC, and 325 healthy subjects to clarify the involvement of HLA-Bw and C, KIRs, and major histocompatibility complex class I chain-related gene A (MICA) gene polymorphisms (rs2596542 and rs1051792) in chronic HCV infection and HCV-related HCC.
|
29731972 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
These results demonstrate that MICA rs2596542G/G, and particularly the rs2596538C/C polymorphism, are associated with the risk of developing HCV-related HCC in a Sicilian population sample.
|
29584564 |
2018 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Recently, two genetic variants, DEPDC5 rs1012068 and MICA rs2596542, were associated with the onset of HCC in Asian subjects with chronic HCV infection.
|
26517016 |
2016 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
An extended region around rs2596542 was genotyped in 1924 HCV-infected patients from the Swiss Hepatitis C Cohort Study (SCCS).
|
23665287 |
2013 |
|
Hepatitis C
|
|
0.100 |
GeneticVariation
|
BEFREE |
Genome-wide association studies (GWAS) have identified three loci (rs17401966 in KIF1B, rs7574865 in STAT4, rs9275319 in HLA-DQ) as being associated with hepatitis B virus-related hepatocellular carcinoma (HBV-related HCC) in a Chinese population, two loci (rs2596542 in MICA, rs9275572 located between HLA-DQA and HLA-DQB) with hepatitis C virus-related HCC (HCV-related HCC) in a Japanese population.
|
24204805 |
2013 |