|
Lupus Erythematosus, Systemic
|
|
0.800 |
GeneticVariation
|
GWASCAT |
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
|
24925725 |
2014 |
|
Lupus Erythematosus, Systemic
|
|
0.800 |
GeneticVariation
|
GWASDB |
GWAS identifies novel SLE susceptibility genes and explains the association of the HLA region.
|
24871463 |
2014 |
|
Lymphoma, Follicular
|
|
0.740 |
GeneticVariation
|
BEFREE |
We confirmed that FL-protective rs2647012-linked variants, in high linkage disequilibrium with the extended haplotype DRB1*15:01-DQA1*01:02-DQB1*06:02, correlate with increased HLA-DQB1 expression.
|
24304973 |
2014 |
|
Lymphoma, Follicular
|
|
0.740 |
GeneticVariation
|
BEFREE |
rs9275517 and rs3117222 in the HLA class II region were validated and inversely associated with FL risk (rs9275517: OR = 0.63, 95% CI = 0.55-0.73, p = 4.03 × 10(-11); rs3117222: OR = 0.66, 95% CI = 0.57-0.77, p = 1.45 × 10(-7)). rs9275517, which is in high linkage disequilibrium with rs2647012 (r2 = 0.9), was no longer associated with FL after conditioning on rs2647012.
|
23025665 |
2012 |
|
Lymphoma, Follicular
|
|
0.740 |
GeneticVariation
|
BEFREE |
The TAP2 SNP was strongly associated with follicular lymphoma (FL, OR = 1.82, 95%CI 1.46-2.26; p = 6.9 × 10(-8)), and was independent of other known loci (rs10484561 and rs2647012) from this region.
|
22911334 |
2012 |
|
Lymphoma, Follicular
|
|
0.740 |
GeneticVariation
|
GWASDB |
Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk.
|
21533074 |
2011 |
|
Lymphoma, Follicular
|
|
0.740 |
GeneticVariation
|
BEFREE |
Haplotype and coalescence analyses indicated that rs2647012 arose on an evolutionarily distinct haplotype from that of rs10484561 and tags a novel allele with an opposite (protective) effect on FL risk.
|
21533074 |
2011 |
|
Lupus Nephritis
|
|
0.700 |
GeneticVariation
|
GWASCAT |
Lupus nephritis susceptibility loci in women with systemic lupus erythematosus.
|
24925725 |
2014 |
|
Liver carcinoma
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.
|
23242368 |
2013 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.
|
21156761 |
2011 |
|
Mature B-Cell Neoplasm
|
|
0.700 |
GeneticVariation
|
GWASCAT |
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.
|
21533074 |
2011 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.
|
19503088 |
2009 |
|
Rheumatoid Arthritis
|
|
0.700 |
GeneticVariation
|
GWASDB |
TRAF1-C5 as a risk locus for rheumatoid arthritis--a genomewide study.
|
17804836 |
2007 |
|
Lymphoma, Non-Hodgkin
|
|
0.020 |
GeneticVariation
|
BEFREE |
Minor allele rs2647012-T is linked to higher expression of HLA-DQB1, rendering a protective effect to NHL risk.
|
28139690 |
2017 |
|
Lymphoma, Non-Hodgkin
|
|
0.020 |
GeneticVariation
|
BEFREE |
Only two variants (rs872071 in IRF4 and rs2647012 in HLA class II) were significantly associated with NHL risk in Chinese, with the ORs of 1.20 (95% CI, 1.05-1.38; P = 0.009) and 1.20 (95% CI, 1.03-1.39; P = 0.018) for per allele of rs872071 and rs2647012, respectively, calculated using an additive model.
|
23455380 |
2013 |