rs267601394, EZH2

N. diseases: 8
Disease: Lymphoma ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Lymphoma
CUI: C0024299
Disease: Lymphoma
0.720 GeneticVariation BEFREE These results suggest that Ezh2(Y641F) induces lymphoma and melanoma through a vast reorganization of chromatin structure, inducing both repression and activation of polycomb-regulated loci. 27135738 2016
Lymphoma
CUI: C0024299
Disease: Lymphoma
0.720 GeneticVariation CLINVAR Selective inhibition of EZH2 by EPZ-6438 leads to potent antitumor activity in EZH2-mutant non-Hodgkin lymphoma. 24563539 2014
Lymphoma
CUI: C0024299
Disease: Lymphoma
0.720 GeneticVariation BEFREE As EZH2 mutations often coincide with other mutations in lymphoma, we combined the expression of EZH2(Y641F) by crossing these transgenic mice with Eµ-Myc transgenic mice. 24802772 2014
Lymphoma
CUI: C0024299
Disease: Lymphoma
0.720 GeneticVariation CLINVAR A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. 23023262 2012
Lymphoma
CUI: C0024299
Disease: Lymphoma
0.720 GeneticVariation CLINVAR A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells. 23023262 2012