|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the subgroup analysis based on cancer type, the TERT rs2736098 with the A allele was 1.299 times more frequent than that with the G allele (OR = 1.299, 95% CI = 1.216-1.386) under the allelic genetic model in lung cancer, and 1.152 times (OR = 1.152, 95% CI = 1.032-1.286) that in bladder cancer.
|
29695979 |
2018 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
Twenty-two variants from 21 genes (APEX1 rs1130409 and rs1760944, ATM rs664677, AXIN2 rs2240308, CHRNA3 rs6495309, CHRNA5 rs16969968, CLPTM1L rs402710, CXCR2 rs1126579, CYP1A1 rs4646903, CYP2E1 rs6413432, ERCC1 rs11615, ERCC2 rs13181, FGFR4 rs351855, HYKK rs931794, MIR146A rs2910164, MIR196A2 rs11614913, OGG1 rs1052133, PON1 rs662, REV3L rs462779, SOD2 rs4880, TERT rs2736098, and TP53 rs1042522) showed significant associations with lung cancer susceptibility with strong cumulative epidemiological evidence.
|
28827732 |
2017 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
In conclusion, in males, the TERT rs2736098 and CLPTM1L rs401681 T alleles are the susceptibility factors for developing lung cancer.
|
28789383 |
2017 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
Additionally, the association was more significant in Asians (OR=1.20; 95% CI=1.07-1.34), while in subsequent analyses stratified by cancer type, the variant rs2736098 was definitely associated with increased lung cancer (OR=1.18; 95% CI=1.07-1.29) and hepatocellular carcinoma risk (OR=1.38; 95% CI=1.20-1.59).
|
27273963 |
2016 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
The TERT rs2736098 polymorphism might affect the susceptibility to lung cancer in Chinese populations.
|
24761905 |
2014 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
The TERT-rs2736098 T allele was also associated with increased lung cancer risk both in adenocarcinoma and squamous cell carcinoma.
|
24861918 |
2014 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results suggest that the rs2736098 polymorphism may contribute to the risk of lung cancer, especially adenocarcinoma, in the Chinese population.
|
24260099 |
2013 |
|
Malignant neoplasm of lung
|
|
0.090 |
GeneticVariation
|
BEFREE |
The TERT rs2735940 g.C > T and rs2736098 g.G > A, and TNKS1 rs6985140 g.A > G were significantly associated with the risk of lung cancer.
|
19773453 |
2009 |