|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
p53-R249S (p53-RS) is frequently detected in human hepatocellular carcinoma (HCC) that is highly associated with hepatitis B infection and aflatoxin B1 exposure.
|
31747859 |
2020 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Yet, less is known about another hotspot p53 mutant, R249S (p53-R249S). p53-R249S is the sole hotspot mutation in hepatocellular carcinoma (HCC) that is highly associated with chronic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin B1 (AFB1).
|
30608603 |
2019 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Here we report a unique mechanism underlying the GOF of p53-R249S (p53-RS), a p53 mutant frequently detected in human hepatocellular carcinoma (HCC) that is highly related to hepatitis B infection and aflatoxin B1.
|
29225033 |
2017 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatitis B virus genetic variation and TP53 R249S mutation in patients with hepatocellular carcinoma in Thailand.
|
23886144 |
2013 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) chronicity and dietary exposure to aflatoxin, a mutagen targeting codon 249 of tumor suppressor TP53 (R249S mutation).
|
23200676 |
2013 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
In regions with high prevalence of chronic hepatitis B virus (HBV) infection and dietary aflatoxin B(1) (AFB(1)) exposure, hepatocellular carcinomas (HCCs) often contain TP53 mutation at codon 249 (R249S).
|
22759751 |
2012 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Most HCC are associated with chronic infection by Hepatitis B Virus while a G → T mutation at codon 249 of the TP53 gene, R249S, specific for exposure to aflatoxin, is detected in tumors for up to 30% of cases.
|
22675488 |
2012 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
Seasonal variation in TP53 R249S-mutated serum DNA with aflatoxin exposure and hepatitis B virus infection.
|
21768053 |
2011 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast, in a cell line that constitutively expresses both p.R249S and the hepatitis B virus antigen HBx (PLC/PRF/5), silencing of either p.R249S or HBx by RNA interference slowed down proliferation, with no additive effects when both factors were silenced.
|
20538734 |
2010 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
It includes integration of hepatitis B virus (HBV) DNA, R249S TP53 (tumor protein p53) mutation in aflatoxin B1-exposed patients, KRAS mutations related to vinyl chloride exposure, hepatocyte nuclear factor 1alpha (HNF1alpha) mutations associated to hepatocellular adenomas and adenomatosis polyposis coli (APC) germline mutations predisposing to hepatoblastomas.
|
16799619 |
2006 |
|
Hepatitis B
|
|
0.100 |
GeneticVariation
|
BEFREE |
A mutation in the tumor suppressor p53 gene resulting in an Arg-->Ser substitution in position 249 is found frequently in human hepatocellular carcinomas associated with hepatitis B infection and with aflatoxin exposure.
|
7605578 |
1995 |