rs28934571, TP53

N. diseases: 31
Disease: Hepatocarcinogenesis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatocarcinogenesis
CUI: C1512409
Disease: Hepatocarcinogenesis
0.020 GeneticVariation BEFREE In addition, an arginine to serine mutation at codon 249 of the p53 tumor suppressor gene is produced, abrogating the function of the tumor suppressor gene, and contributing to hepatocarcinogenesis. 24078988 2013
Hepatocarcinogenesis
CUI: C1512409
Disease: Hepatocarcinogenesis
0.020 GeneticVariation BEFREE We suggest that p.R249S may contribute to hepatocarcinogenesis through interaction with HBx, conferring a subtle growth advantage at early steps of the transformation process, but that this interaction is not required for progression to advanced HCC. 20538734 2010