rs28934576, TP53

N. diseases: 78
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Tumor Cell Invasion
CUI: C1269955
Disease: Tumor Cell Invasion
0.030 GeneticVariation BEFREE In this study, we demonstrate that the hotspot mutation, p53-R273H, promotes cell migration, invasion in vitro and tumor metastasis in vivo. p53-R273H significantly represses expression of DLX2, a homeobox protein involved in cell proliferation and pattern formation. 28796261 2017
Tumor Cell Invasion
CUI: C1269955
Disease: Tumor Cell Invasion
0.030 GeneticVariation BEFREE Moreover, ATF3 appeared to suppress R175H- and R273H-mediated cancer cell migration and invasion as a consequence of preventing the transcription factor p63 from inactivation by mutp53. 24554706 2014
Tumor Cell Invasion
CUI: C1269955
Disease: Tumor Cell Invasion
0.030 GeneticVariation BEFREE R273H expression in p53-null cancer cell SK-OV-3 and Saos-2 did not significantly affect cell invasion and migration activities. 17636407 2007