rs28934576, TP53

N. diseases: 78
Disease: Mammary gland tumor ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Mammary gland tumor
CUI: C4087397
Disease: Mammary gland tumor
0.010 GeneticVariation BEFREE Heterozygous p53(R270H/+)WAPCre mice (with mammary gland-specific expression of the p53.R270H mutation, equivalent to human R273H, at physiologic levels) develop mammary tumors at high frequency, indicating that the R270H mutation predisposes for mammary gland tumor development and acts in a dominant-negative manner in early stages of tumorigenesis. 16166291 2005