Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The rs2910164 CG or GG genotype was associated with a significantly decreased risk for lung cancer compared to that of the CC genotype (adjusted odds ratio=0.80, 95% confidence interval=0.66-0.96, P=0.02).
|
24144839 |
2014 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our study suggested that the miR-196a2 gene rs11614913 polymorphism and the miR-146a gene rs2910164 polymorphism might associate with lung cancer risk.
|
25077922 |
2014 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that the rs2910164C>G in pre-miR-146a may contribute to genetic susceptibility to lung cancer, and that miR-146a might be involved in lung cancer development.
|
24144839 |
2014 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The individuals with both risk genotypes of miRNA SNPs and exposure to risk factor (cooking oil fumes) were in a higher risk of lung cancer than persons with only one of the two risk factors (ORs were 1.91, 1.05 and 1.41 for miR-146a rs2910164, ORs were 1.94, 1.23 and 1.34 for miR-196a2 rs11614913, ORs were 2.06, 1.41 and 1.68 for miR-608 rs4919510, ORs were 1.76, 0.82 and 1.07 for miR-27a rs895819, and ORs were 2.13, 1.15 and 1.02 for miR-423 rs6505162, respectively).
|
26083623 |
2015 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
In contrast to these results, the same allelic variant of rs2910164 was found to confer an increased risk of developing lung cancer.
|
26337564 |
2015 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
For miR-146a rs2910164, individuals carrying heterozygous CG or homozygous GG genotype had decreased risks of lung cancer compared with those carrying homozygous wild CC genotype (adjusted odds ratios were 0.76 and 0.64, 95% confidence intervals were 0.59-0.99 and 0.46-0.90, P values were 0.039 and 0.010, respectively).
|
26973201 |
2016 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggest that miR-146a rs2910164C>G and miR-423 rs6505162C>A polymorphisms may contribute to genetic susceptibility to lung cancer and lung adenocarcinoma in Chinese non-smoking females.
|
26973201 |
2016 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
Thus, miR-146a rs2910164 polymorphism may influence susceptibility to lung cancer in Chinese nonsmoking females through targeting TRAF6.
|
27911870 |
2017 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
As a result, 15 SNPs on or near 12 genes and one miRNA with strong evidence of association with lung cancer risk were identified, including TERT (rs2736098), CHRNA3 (rs1051730), AGPHD1 (rs8034191), CLPTM1L (rs401681 and rs402710), BAT3 (rs3117582), TRNAA (rs4324798), ERCC2 (Lys751Gln), miR-146a2 (rs2910164), CYP1B1 (Arg48Gly), GSTM1 (null/present), SOD2 (C47T), IL-10 (-592C/A and -819C/T), and TP53 (intron 6).
|
29110844 |
2017 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer and nasopharyngeal carcinoma.
|
29127520 |
2018 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results indicated that lung cancer risk was significantly associated with miRNA-196a2 rs11614913 and miRNA-146a rs2910164.
|
29750042 |
2018 |
Carcinoma of lung
|
|
0.100 |
GeneticVariation
|
BEFREE |
These findings suggested that SNPs rs71428439 (miR-149), rs2910164 (miR-146a), rs928508 (mir-30c-1) and rs629367 (let-7a-2) were associated with the lung cancer prevalence, polymorphisms of rs11614913 (miR-196a-2) and rs9280508 (miR-30c-1) significantly influenced the patients' response to platinum-based chemotherapy, which may serve as potential clinical biomarkers to predict lung cancer risk and platinum-based chemotherapy response.
|
30069329 |
2018 |