Our meta-analysis demonstrated that increased risk of ADs w</span>as significantly associated with GC genotype in Asians for SNP rs2910164 in the stratified analyses by ethnicity; there was increased OR for GC genotype compared with that for GG+CC genotype in other disease subgroup, respectively (OR=0.89, 95% CI=0.79-0.99; OR=0.84, 95% CI=0.75-0.95, respectively).
The rs2910164 polymorphism has been identified as a functional variant, which affects the transcription and expression level of miR-146a and, thereby, contributes to the pathogenesis of several inflammatory and autoimmune diseases.