|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Previous studies have shown that miRNA-146a rs2910164 polymorphism can be associated with the pathogenesis of liver diseases such as hepatocellular carcinoma.
|
30624803 |
2019 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We evaluated the associations of <i>miR-499A</i>>G (rs3746444), <i>miR-149C</i>>T (rs2292832), <i>miR-196a2T</i>>C (rs11614913), and <i>miR-146aG</i>>C (rs2910164) with HCC susceptibility in 100 HCC patients (70 males and 30 females) and 120 healthy controls (70 males and 50 females), using the PCR-restriction fragment length polymorphism method.
|
30215231 |
2019 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the subgroup analysis for cancer types, miR-146a rs2910164 polymorphism was associated with the susceptibility of lung cancer (CC vs. GG: OR 1.275, 95% CI 1.117-1.455 (P = 0.000); CC + CG vs. GG: OR 1.166, 95% CI 1.052-1.293 (P = 0.003); CC vs. CG + GG: OR 1.239, 95% CI 1.116-1.375 (P = 0.000); C vs. G OR 1.151, 95% CI 1.080-1.227 (P = 0.000)) and nasopharyngeal carcinoma (CC vs. GG: OR 1.713, 95% CI 1.183-2.479 (P = 0.004); CC vs. CG + GG: OR 1.672, 95% CI 1.330-2.103 (P = 0.000); C vs. G: OR 1.400, 95% CI 1.181-1.659 (P = 0.000)), but it was not associated with hepatocellular carcinoma and gastric cancer.
|
29127520 |
2018 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, hsa-<i>mir-146a</i> rs2910164 and hsa-<i>mir-34b/c</i> rs4938723 could be biomarkers for the HCC risk while hsa-<i>mir-196a-2</i> rs11614913 and hsa-<i>mir-149</i> rs2292832 had potential to be biomarkers for HBV-related HCC risk.
|
29976775 |
2018 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In conclusion, miR-146a C>G (rs2910164) can increase HBV-related HCC risk while miR-196a-2 C>T (rs11614913) may decrease the risk of HBV- and HCV-related HCC, especially in the Chinese population.
|
28148887 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our findings supported the proposition that the polymorphisms of miR-146a rs2910164, miR-196a2 rs11614913, and miR-196a2 rs11614913 may contribute to the susceptibility of HCC.
|
28188097 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
To evaluate the association between four common miRNAs (miR-146a rs2910164; miR-149 rs2292832; miR-196a2 rs11614913 and miR-499 rs3746444) and HCC risk, an updated meta-analysis was performed.
|
28499985 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Our meta-analysis supports that the miR-146a rs2910164 polymorphism contributes to the risk of HCC from currently available evidence.
|
27886162 |
2017 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
Predictive role of miR-146a rs2910164 (C>G), miR-149 rs2292832 (T>C), miR-196a2 rs11614913 (T>C) and miR-499 rs3746444 (T>C) in the development of hepatocellular carcinoma.
|
26823863 |
2015 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We conclude that rs2910164 in miR-146a may confer susceptibility to HCC, especially in the Chinese population.
|
25108400 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
The results suggest that the miR-146a rs2910164 polymorphism contributes to increased HCC susceptibility, especially in Asian populations.
|
25546664 |
2014 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In addition, subgroup analysis revealed of rs2910164 C allele decreased hepatocellular carcinoma (HCC), cervical cancer and prostate cancer risk among Chinese population.
|
23750236 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In particular, the association between SNPs in miRNA196a-2 (rs11614913) and miRNA146a (rs2910164) and HCC has been investigated.
|
24377545 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
In the tumor type subgroup analysis, rs2910164 C allele decreased the risk of hepatocellular carcinoma (C vs. G: OR = 0.89, 95% CI = 0.80-1.00) and cervical squamous cell carcinoma (C vs. G: OR = 0.72, 95% CI = 0.62-0.84).
|
23292097 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that miR-146a rs2910164 and miR-499 rs3746444 polymorphisms may not be associated with the risk of HCC, especially for Asian population.
|
23437296 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
We did not find a significant association of miR-146aG>C rs2910164 and miR-499A>G rs3746444 polymorphisms with hepatocellular carcinoma risk in the Chinese population.
|
24301908 |
2013 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
This meta-analysis suggests that two common SNPs rs2910164 and rs11614913 are not associated with the risk of HCC.
|
22768213 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A common G/C polymorphism (rs2910164) in the precursor (pre-) miR-146a gene engaged in NF-κB signaling and apoptosis pathways has been reported to modulate the genetic risk of hepatocellular carcinoma by increased G-allelic production of mature miR-146a.
|
22893469 |
2012 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
No statistically significant differences were found in the allele or genotype distributions of the miR-146a rs2910164 polymorphism among HCC and cancer-free control subjects (p>0.05).
|
21807077 |
2011 |
|
Liver carcinoma
|
|
0.100 |
GeneticVariation
|
BEFREE |
A G/C polymorphism in miRNA-146a (rs2910164) was shown to be associated with the risk of hepatocellular carcinoma.
|
20721625 |
2011 |