rs3024490, IL10;IL19

N. diseases: 11
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.710 GeneticVariation BEFREE Our findings not only confirmed the association of IL10/rs1800871 and IL23R-IL12RB2/rs924080 with BD but also identified 2 susceptibility single nucleotide polymorphisms in IL10 and IL23R-IL12RB2 (rs3024490 and rs12141431) with BD in Han Chinese. 27464962 2017
Behcet Syndrome
CUI: C0004943
Disease: Behcet Syndrome
0.710 GeneticVariation GWASDB Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1. 23291587 2013
Nephritis, Interstitial
CUI: C0027707
Disease: Nephritis, Interstitial
0.010 GeneticVariation BEFREE The homozygous minor allele in IL-10 +434T (rs2222202) and IL-10+504G (rs3024490) was found in all patients with TIN or TINU syndrome while the frequency of these minor alleles in the control population was 44% and 23%, respectively (p <0.001). 30779760 2019
Tubulointerstitial nephritis and uveitis
0.010 GeneticVariation BEFREE The homozygous minor allele in IL-10 +434T (rs2222202) and IL-10+504G (rs3024490) was found in all patients with TIN or TINU syndrome while the frequency of these minor alleles in the control population was 44% and 23%, respectively (p <0.001). 30779760 2019
Nephritis, Tubulointerstitial
CUI: C0041349
Disease: Nephritis, Tubulointerstitial
0.010 GeneticVariation BEFREE The homozygous minor allele in IL-10 +434T (rs2222202) and IL-10+504G (rs3024490) was found in all patients with TIN or TINU syndrome while the frequency of these minor alleles in the control population was 44% and 23%, respectively (p <0.001). 30779760 2019
Metabolic Syndrome X
CUI: C0524620
Disease: Metabolic Syndrome X
0.010 GeneticVariation BEFREE Individuals with and without MetS were compared according to their plasma inflammatory biomarkers, fatty acid profile, and genotype frequency of the IL1B (rs16944, rs1143623, rs1143627, rs1143634 and rs1143643), IL6 (rs1800795, rs1800796 and rs1800797) and IL10 (rs1554286, rs1800871, rs1800872, rs1800890 and rs3024490) genes SNP. 28268030 2018
Cerebral Palsy
CUI: C0007789
Disease: Cerebral Palsy
0.010 GeneticVariation BEFREE IL-10 polymorphisms and protein association analysis showed that the TT genotype had higher plasma IL-10 protein levels compared to the GG + GT genotype at rs3024490 (11.14 ± 7.27 vs. 7.44 ± 6.95 pg/ml, <i>p</i> = 0.045, respectively) in CP cases. 29623066 2018
Tuberculosis, Pulmonary
CUI: C0041327
Disease: Tuberculosis, Pulmonary
0.010 GeneticVariation BEFREE We found correlations between one SNP in IL6 (rs2069837 <i>p</i> = 6.63E-11), seven SNPs in <i>IL10</i> (rs1554286 <i>p</i> = 6.87E-20, rs1518111 <i>p</i> = 6.11E-11, rs3021094 <i>p</i> = 6.75E-29, rs3790622 <i>p</i> = 2.40E-06, rs3024490 <i>p</i> = 6.73E-11, rs1800872 <i>p</i> = 6.18E-11, rs1800871 <i>p</i> = 6.73E-11) and incidences of PTB. 29662655 2018
Ankylosing spondylitis
CUI: C0038013
Disease: Ankylosing spondylitis
0.010 GeneticVariation BEFREE IL10 rs1878672 and rs3024490 polymorphisms obviously increase the susceptibility to AS, but not TNF-α rs3093662. 26823867 2015
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.010 GeneticVariation BEFREE This study found that rs3024490 G/T allele, located in the intron 1 region and highly prevalent in Chinese populations, was significantly different between the chronic HBV infection cases and the acute infection controls in single allele analysis, genetic models analysis, and haplotypes analysis. 24631780 2014
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.010 GeneticVariation BEFREE This suggested that the rs3024490 within IL-10 was associated with susceptibility to chronic hepatitis B in a Chinese Han population. 24631780 2014
Uveitis
CUI: C0042164
Disease: Uveitis
0.010 GeneticVariation BEFREE The results demonstrate that uveitis is associated with three haplotype-tagging SNPs (htSNPs) in the IL10 gene: htSNP2 (rs6703630), htSNP5 (rs2222202), and htSNP6 (rs3024490). 20335604 2010