rs3077, HLA-DPA1

N. diseases: 16
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE Single nucleotide polymorphisms (SNPs) in HLA-DP (rs9277535 and rs3077) and HLA-DQ (rs2856718 and rs7453920) have been repeatedly associated with chronic hepatitis B and spontaneous HBV clearance. 28882445 2017
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE In genome-wide association studies (GWAS), the human leukocyte antigen (HLA) gene polymorphisms rs3077 and rs9277535 were identified to be associated with chronic hepatitis B. HLA genes have been linked to immune response to infectious agents. 28119119 2017
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation GWASCAT Genetic variants in five novel loci including CFB and CD40 predispose to chronic hepatitis B. 25802187 2015
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE Of these variants, SNPs rs3077 and rs9277535 in HLA-DP on chromosome 6 show the strongest evidence for association with CHBVI and with viral clearance. 24846544 2014
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation GWASCAT A genome-wide association study identified new variants associated with the risk of chronic hepatitis B. 23760081 2013
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE We also found that the HLA-DPA1 and HLA-DPB1 genes were significantly associated with protective effects against chronic hepatitis B (CHB) in Japanese, Korean and other Asian populations, including Chinese and Thai individuals (P(meta) = 4.40×10⁻¹⁹ for rs3077 and P(meta) = 1.28×10⁻¹⁵ for rs9277542). 22737229 2012
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE A genome-wide association study identified single nucleotide polymorphisms (SNPs) rs3077 and rs9277535 located in the 3' untranslated regions of human leukocyte antigen (HLA) class II genes HLA-DPA1 and HLA-DPB1, respectively, as the independent variants most strongly associated with chronic hepatitis B. 21346778 2011
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.760 GeneticVariation BEFREE Chronic hepatitis B susceptibility loci in HLA-DP region (rs3077 and rs9277535) identified by genome-wide scan in Japanese population were validated in Chinese population. 21408128 2011