|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
Here, we analysed the effect of T1D-associated major HLA class II haplotypes and seven single nucleotide polymorphisms in six non-HLA genes [INS (rs689), PTPN22 (rs2476601), IL2RA (rs12722495 and rs2104286), PTPN2 (rs45450798), CTLA4 (rs3087243) and ERBB3 (rs2292239)] on peripheral blood Treg frequencies.
|
31808541 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
For the case-control studies, 1) the rs3087243 polymorphism was significantly associated with T1D [allele (fixed: odds ratio and 95% confidence interval (CI) = 1.249 (1.194-1.307), P < 0.001; random: odds ratio and 95%CI = 1.601 (1.103-2.325), P = 0.013)] [genotype (GG versus GA+AA: odds ratio and 95%CI = 1.249 (1.164-1.341), P < 0.001)], 2) there was no evidence to show that this association was accounted for in any study, and 3) there was no evidence for publication bias.
|
24390983 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
These patients had a stronger association with CTLA4 (odds ratio [OR] = 1.49 for the G allele of the single nucleotide polymorphism rs3087243; 95% CI = 1.29-1.72) than did the TPOAbs-negative patients (p = 0.0004; OR = 1.16; 95% CI = 1.10-1.24) or type 1 diabetes patients overall (OR = 1.20; 95% CI = 1.13-1.27).
|
17334650 |
2007 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
Genetic polymorphisms (HLA haplotypes; rs231806, rs231775, and rs3087243 in CTLA4; rs763361 in CD226; and rs706778 in CD25) and T1D-associated autoantibodies were analyzed.
|
25980680 |
2015 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.860 |
GeneticVariation
|
BEFREE |
In the case-only statistical interaction analysis between rs3772534 and rs3087243, there was also no support for an effect (1994 T1D affected offspring, and 3215 cases, P=0.92).
|
17209142 |
2007 |
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
The results of our study suggest no significant association between CD28 rs1980422, CCL5 rs2107538, CTLA-4 exon 1 +49A>G rs231775 and rs3087243 gene polymorphisms and RA in the Polish population.
|
27988812 |
2017 |
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Markers associated with RA in populations of European ancestry (rs3087243 [+60C/T] and rs231775 [+49A/G]) were not replicated in African Americans.
|
19300490 |
2009 |
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
In conclusion, our results suggest that the -319C/+49G/CT60G haplotype of CTLA-4 gene is a genetic marker of susceptibility to RA in Western Mexico, whereas the rs3087243 SNP confers protection against this disease.
|
23703660 |
2013 |
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-analysis.
|
20498205 |
2010 |
|
Rheumatoid Arthritis
|
|
0.850 |
GeneticVariation
|
BEFREE |
We studied RA risk associated with PTPN22 (rs2476601), PADI-4 (rs2240340), and CTLA-4 (rs3087243) in the Nurses' Health Study (NHS) and NHSII.
|
18462498 |
2008 |
|
Autoimmune Diseases
|
|
0.810 |
GeneticVariation
|
BEFREE |
We have evaluated functional polymorphism (rs3087243; in literature known also as CTLA4 CT60) in the cytotoxic T lymphocyte antigen 4 (CTLA4) gene, previously associated with several autoimmune diseases, for potential association with inflammatory bowel diseases (IBD).
|
20491567 |
2010 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
The aim of our study was to investigate whether the CTLA4 polymorphisms, including -318C/T (rs5742909), +49A/G (rs231775), and CT60 (rs3087243), were associated with GD and HD in Han Chinese adults and children.
|
27111218 |
2016 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
A significant association was found between the CTLA-4 CT60 polymorphism (rs3087243) and GD, with regard to comparisons between allele and genotype frequencies (all p < 0.001).
|
24697361 |
2014 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In conclusion, our data support that the rs3087243 and rs231775 polymorphisms within the <i>CTLA4</i> gene confer genetic susceptibility to GD.
|
29299173 |
2017 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
In this study, we investigated 329 (240 TBII-positive and 89 TBII-negative) GD patients and 378 controls for the polymorphisms in HLA-A, -DPB1 and CTLA4 (CT60, rs3087243, A/G) to investigate the contribution of these factors in the susceptibility to GD.
|
20300120 |
2010 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
*642AT(8_33)(AT<sub>16-21</sub>)/CT60(rs3087243)G/Jo31(rs11571302)G/ICOSc.1554+4GT(8_15)(m) and TCA(AT<sub><16</sub>)GT(m) haplotypes increased risk of Graves' disease, especially in males, as well as overall Graves' orbitopathy development with severe outcome.
|
27638540 |
2017 |
|
Graves Disease
|
|
0.060 |
GeneticVariation
|
BEFREE |
Interactions among the SNPs of rs231775, rs231779 and rs3087243 significantly increase the susceptibility to GD.
|
30223781 |
2018 |
|
Primary biliary cirrhosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
In haplotype analyses, one haplotype [haplotype 1 (CGGA)] at rs5742909, rs231775, rs3087243, and rs231725, was significantly associated with susceptibility to both AMA-positive PBC and overall PBC.
|
20557968 |
2010 |
|
Primary biliary cirrhosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
PubMed and the Chinese National Knowledge Infrastructure (CNKI) database were used to search correlative literatures, and the documents which were about the relationships between the polymorphisms of <i>CTLA4</i> (rs231775, rs231725, rs3087243, and rs5742909) and PBC were collected as of June 2016.
|
28642883 |
2017 |
|
Primary biliary cirrhosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The G allele of rs231775 is a risk factor for PBC, while AA genotype of rs3087243 and GG, GA and G allele of rs231725 show negative associations with PBC.
|
22414241 |
2012 |
|
Primary biliary cirrhosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
The CTLA-4 haplotype 1 (rs231775 G, rs231777 C, rs3087243 G, rs231725 A; GCGA) was a risk factor for PBC susceptibility but a protective factor for PBC progression.
|
21594562 |
2011 |
|
Primary biliary cirrhosis
|
|
0.050 |
GeneticVariation
|
BEFREE |
Although no significant differences in clinical or biochemical characteristics between patients with PBC and PBC-AITD were seen (all P>0.05), liver function tests and metabolic traits in PBC patients were significantly (all P<0.05) affected by the CTLA4 (rs3087243), MMEL1 (rs2843403), PTPN22 (rs2476601) and RNASET2 (rs9355610) variants.
|
28922436 |
2017 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
With respect to the rs3087243 (+6230G>A) polymorphism of CTLA4, the first sister had type 1 diabetes and AITD and had the GG genotype, whereas the second and third sisters, who had type 1 diabetes without AITD, had the AG genotype.
|
19506323 |
2009 |
|
Autoimmune thyroid disease (AITD)
|
|
0.030 |
GeneticVariation
|
BEFREE |
Taken together, our study suggested that the CT60 polymorphism (rs3087243) in CTLA-4 gene might confer susceptibility to the AITDs (GD/HT).
|
24697361 |
2014 |