rs3173615, TMEM106B

N. diseases: 12
Disease: Frontotemporal dementia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.030 GeneticVariation BEFREE Recent studies found that two polymorphisms (rs363371 and rs363324) in VMAT2 might be a risk factor for Parkinson's disease (PD) in Caucasians, while the two other variants (rs1990622 and rs3173615) in TMEM106B increased the risk for frontotemporal dementia (FTD). 28477711 2017
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.030 GeneticVariation BEFREE The major allele of SNP rs3173615 is a risk factor in sporadic FTD, whereas the minor allele seems protective in GRN- and C9orf72-mediated FTD. 28888721 2017
Frontotemporal dementia
CUI: C0338451
Disease: Frontotemporal dementia
0.030 GeneticVariation BEFREE TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia. 23742080 2013