rs3184504, SH2B3;ATXN2

N. diseases: 92
Disease: Cardiovascular Diseases ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.720 GeneticVariation BEFREE A SH2B3 missense variant (rs3184504) is associated with cardiovascular diseases plus breast, colorectal and lung cancers, with highly correlated variants across the ATXN2/SH2B3/BRAP locus linked to parental age at death, suggesting a geroscience common mechanism of aging and disease. 31428775 2019
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.720 GeneticVariation GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
Cardiovascular Diseases
CUI: C0007222
Disease: Cardiovascular Diseases
0.720 GeneticVariation BEFREE We found that BP, CAD and IS shared for phosSNPs in loci that contain functional genes involve in cardiovascular diseases, e.g., rs11556924 (ZC3HC1), rs1971819 (ICA1L), rs3184504 (SH2B3), rs3739998 (JCAD), rs903160 (SMG6). 31456518 2019