|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results suggest that the 135G/C polymorphism of the RAD51, Thr241Met polymorphism of XRCC3 and Arg188His polymorphism of XRCC2 can be independent markers of breast cancer risk in Pakistan.
|
25556451 |
2014 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Our results suggest that the 135G/C polymorphism of the RAD51, Thr241Met polymorphism of XRCC3 and Arg188His polymorphism of XRCC2 can be independent markers of breast cancer risk in Pakistan.
|
25556451 |
2014 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
No significant association was observed between the XRCC2 Arg188His polymorphism and breast cancer susceptibility (dominant model: OR = 0.94, 95%CI = 0.86-1.04, P = 0.232).
|
24621646 |
2014 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
No significant association was observed between the XRCC2 Arg188His polymorphism and breast cancer susceptibility (dominant model: OR = 0.94, 95%CI = 0.86-1.04, P = 0.232).
|
24621646 |
2014 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the present study, we showed the association between RAD51 G135C polymorphism and the incidence of breast cancer (p < 0.0001), but found no significant association with XRCC2 Arg188His or XRCC3 Thr241Met polymorphism.
|
21701125 |
2011 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In the present study, we showed the association between RAD51 G135C polymorphism and the incidence of breast cancer (p < 0.0001), but found no significant association with XRCC2 Arg188His or XRCC3 Thr241Met polymorphism.
|
21701125 |
2011 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
In summary, the present meta-analysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk.
|
20127279 |
2010 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, when the population was stratified according to breast feeding (women that breast fed and women that never breast fed) it is observed, in women that never breast fed, that the heterozygous individuals for the XRCC2 (Ex3+442G>A, R188H, rs3218536) polymorphism have a decreased risk for breast cancer [adjusted OR=0.45; 95% CI=0.22-0.92] (P=0.03).
|
20004634 |
2010 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
However, when the population was stratified according to breast feeding (women that breast fed and women that never breast fed) it is observed, in women that never breast fed, that the heterozygous individuals for the XRCC2 (Ex3+442G>A, R188H, rs3218536) polymorphism have a decreased risk for breast cancer [adjusted OR=0.45; 95% CI=0.22-0.92] (P=0.03).
|
20004634 |
2010 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
In summary, the present meta-analysis suggests that the XRCC2 Arg188His is not directly associated with breast cancer risk.
|
20127279 |
2010 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
None of these tagging SNPs was associated with breast cancer risk, with the exception of XRCC2 rs3218536, R188H, which showed some evidence of a protective association for the rare allele [per allele odds ratio, 0.89; 95% confidence intervals (95% CI), 0.80-0.99; P trend = 0.03].
|
19064565 |
2008 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
None of these tagging SNPs was associated with breast cancer risk, with the exception of XRCC2 rs3218536, R188H, which showed some evidence of a protective association for the rare allele [per allele odds ratio, 0.89; 95% confidence intervals (95% CI), 0.80-0.99; P trend = 0.03].
|
19064565 |
2008 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
Genotyping was conducted for polymorphisms in four genes involved in repair of radiation-induced DNA damage, the double-strand break repair pathway: X-ray cross-complementing group 3 (XRCC3) codon 241 Thr/Met, Nijmegen breakage syndrome 1 (NBS1) codon 185 Glu/Gln, X-ray cross-complementing group 2 (XRCC2) codon 188 Arg/His, and breast cancer susceptibility gene 2 (BRCH2) codon 372 Asn/His.
|
16214912 |
2005 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Genotyping was conducted for polymorphisms in four genes involved in repair of radiation-induced DNA damage, the double-strand break repair pathway: X-ray cross-complementing group 3 (XRCC3) codon 241 Thr/Met, Nijmegen breakage syndrome 1 (NBS1) codon 185 Glu/Gln, X-ray cross-complementing group 2 (XRCC2) codon 188 Arg/His, and breast cancer susceptibility gene 2 (BRCH2) codon 372 Asn/His.
|
16214912 |
2005 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
We observed that the XRCC2 R188H polymorphism modified the association of plasma alpha-carotene level and breast cancer risk (test for ordinal interaction, P=0.03); the significantly decreased risk seen overall for women in the highest quartile of plasma alpha-carotene was only present among 188H non-carriers (the top quartile versus the bottom quartile; multivariate odds ratio, 0.55; 95% confidence interval, 0.40-0.75).
|
14578164 |
2004 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
We observed that the XRCC2 R188H polymorphism modified the association of plasma alpha-carotene level and breast cancer risk (test for ordinal interaction, P=0.03); the significantly decreased risk seen overall for women in the highest quartile of plasma alpha-carotene was only present among 188H non-carriers (the top quartile versus the bottom quartile; multivariate odds ratio, 0.55; 95% confidence interval, 0.40-0.75).
|
14578164 |
2004 |
|
Malignant neoplasm of breast
|
|
0.090 |
GeneticVariation
|
BEFREE |
Carriage of the rare allele of XRCC2 R1</span>88H was associated with breast cancer overall [odds ratio 1.3; 95% confidence interval (CI)=(1.0, 1.8)] and when younger-onset cases with a positive family history were compared with older controls with no family history [odds ratio 1.9; 95% CI=(1.0, 3.8)].
|
12023985 |
2002 |
|
Breast Carcinoma
|
|
0.090 |
GeneticVariation
|
BEFREE |
Carriage of the rare allele of XRCC2 R1</span>88H was associated with breast cancer overall [odds ratio 1.3; 95% confidence interval (CI)=(1.0, 1.8)] and when younger-onset cases with a positive family history were compared with older controls with no family history [odds ratio 1.9; 95% CI=(1.0, 3.8)].
|
12023985 |
2002 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
The obtained results indicate that XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be positively associated with the incidence of ovarian carcinoma in the population of Polish women.
|
26801223 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
In conclusion, this meta-analysis indicates that XRCC2 rs3218536 and ERCC2 rs13181 polymorphisms may not be associated with the risk of OC.
|
27863412 |
2016 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
Overall, a significant association was found between the Arg188His polymorphism and ovarian cancer risk when all studies were pooled into the meta-analysis (Arg/Arg vs His/His: OR = 1.85, 95%CI = 1.15-3.00; Arg/Arg vs Arg/His: OR = 1.17, 95%CI = 1.03-1.32; dominant model: OR = 0.84, 95%CI = 0.74-0.95; recessive model: OR = 1.69, 95%CI = 1.05-2.70).
|
26400309 |
2015 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
The current meta-analysis indicated that the Arg188His polymorphism in the XRCC2 gene might be a risk factor for ovarian cancer.
|
24414483 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
Interestingly, XRCC2 G>A (rs3218536) polymorphism might reduce the risk of ovarian cancer.
|
24599673 |
2014 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
The aim of the present study was to evaluate the role of SNPs in three genes, XRCC2 (R188H), ERCC2 (K751Q) and CDKN1B (V109G) which are with moderate risk for ovarian cancer susceptibility in Egyptian women.
|
23277402 |
2013 |
|
Carcinoma, Ovarian Epithelial
|
|
0.070 |
GeneticVariation
|
BEFREE |
The XRCC2 R188H polymorphism was associated with a modest reduction in EOC risk: OR for heterozygotes was 0.8 (95% confidence interval [CI] = 0.7-1.0) and for rare homozygotes 0.3 (0.1-0.9).
|
15924337 |
2005 |