ASTHMA-RELATED TRAITS, SUSCEPTIBILITY TO, 2
|
|
0.700 |
SusceptibilityMutation
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CLINVAR |
|
|
|
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
The functional A/T single nucleotide polymorphism (SNP) rs324981 in the neuropeptide S receptor gene (NPSR1) has repeatedly been associated with panic disorder and might partly drive function respectively dysfunction of the neural "fear network".
|
31734525 |
2019 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
The more active T allele of the functional rs324981 variant in the neuropeptide S receptor gene (NPSR1) is associated with panic disorder (PD) and distorted cortico-limbic activity during emotion processing in healthy adults and PD patients.
|
26503268 |
2017 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system.
|
26680586 |
2016 |
Panic Disorder
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|
0.090 |
GeneticVariation
|
BEFREE |
Neuropeptide S is involved in anxiety and arousal modulation, and the functional polymorphism Asn107Ile (rs324981, A > T) of the neuropeptide S receptor gene (NPSR1) is associated with panic disorder and anxiety/fear-related traits.
|
24331455 |
2014 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
A coding variation (Asn107Ile) of the NPS receptor gene (NPSR1) was associated with panic disorder and schizophrenia.
|
23680103 |
2013 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
The T allele of rs324981, which goes along with enhanced receptor function, was associated with panic disorder, increased anxiety sensitivity in healthy subjects, attenuated prefrontal brain activation and elevated amygdala responses to fear-relevant stimuli.
|
23103692 |
2013 |
Panic Disorder
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|
0.090 |
GeneticVariation
|
BEFREE |
A functional variant within this gene leads to an amino-acid exchange (rs324981, Asn107Ile) resulting in a gain-of-function in the Ile107 variant which was recently associated with panic disorder in two independent studies.
|
22078257 |
2012 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
Recently, a functional polymorphism in the NPSR gene (rs324981 A/T) has been associated with panic disorder and anxiety sensitivity.
|
21525857 |
2011 |
Panic Disorder
|
|
0.090 |
GeneticVariation
|
BEFREE |
The more active NPSR rs324981 T allele was found to be associated with panic disorder in the female subgroup of patients in both samples as well as in a meta-analytic approach.
|
20603625 |
2011 |
Anxiety Disorders
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|
0.070 |
GeneticVariation
|
BEFREE |
Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms.
|
27990720 |
2017 |
Anxiety Disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system.
|
26680586 |
2016 |
Anxiety Disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders.
|
22404660 |
2014 |
Anxiety Disorders
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|
0.070 |
GeneticVariation
|
BEFREE |
Since stress is critically involved in the pathogenesis of anxiety disorders, we tested the association between rs324981 and stress reactivity in 196 healthy males.
|
23466585 |
2013 |
Anxiety Disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
The current results are in line with earlier imaging genetic studies and suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response.
|
23103692 |
2013 |
Anxiety Disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
All subjects were genotyped for the functional NPSR1 A/T (Asn(107)Ile) variant (rs324981) and characterized for anxiety sensitivity using the Anxiety Sensitivity Index (ASI).
|
23319044 |
2013 |
Anxiety Disorders
|
|
0.070 |
GeneticVariation
|
BEFREE |
Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity.
|
21525857 |
2011 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
Amongst neuropeptide S receptor gene functional sequence variants, the T-allele [asparagine(107)isoleucine, NPSR1 rs324981] has been identified as a risk factor for increased anxiety/overinterpretation of bodily symptoms.
|
27990720 |
2017 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
In recent years, accumulating data from various labs have demonstrated an A/T single-nucleotide polymorphism (SNP) resulting in (Asn107Ile) switch in the human NPSR gene as the risk factor for various psychiatric disorders such as panic disorder, post traumatic syndrome, alcohol use disorders and enhanced anxiety sensitivity, although, this is in stark contrast to the findings made in animal models which have consistently projected the anxiolytic nature of this peptide system.
|
26680586 |
2016 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
Thus, a gene-environment interaction (G × E) study of the neuropeptide S receptor gene (NPSR) A/T polymorphism (rs324981) and life events was conducted with respect to anxiety sensitivity (AS) as an intermediate phenotype of anxiety disorders.
|
22404660 |
2014 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
All subjects were genotyped for the functional NPSR1 A/T (Asn(107)Ile) variant (rs324981) and characterized for anxiety sensitivity using the Anxiety Sensitivity Index (ASI).
|
23319044 |
2013 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
The current results are in line with earlier imaging genetic studies and suggest a potential protective function of the NPSR1 rs324981 A/A genotype against pathologically enhanced anxiety that might be explained by stronger reflective prefrontal regulation over the subcortical fear response.
|
23103692 |
2013 |
Anxiety
|
|
0.060 |
GeneticVariation
|
BEFREE |
Thereby, NPSR rs324981 apparently causes an indirect effect on anxiety-related traits and potentially contributes to the pathogenesis of anxiety disorders by shaping fear-related limbic activity.
|
21525857 |
2011 |
Asthma
|
|
0.030 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms (SNPs) close to the gain-of-function substitution, Asn(107)Ile (rs324981, A>T), in Neuropeptide S Receptor 1 (NPSR1) have been associated with asthma.
|
28463995 |
2017 |
Asthma
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|
0.030 |
GeneticVariation
|
BEFREE |
Notably, this inhibition is absent in the asthma-linked N107I variant of NPSR, suggesting that residue 107 interacts with the aforementioned regulatory region of NPS.
|
16790440 |
2006 |