rs34536443, TYK2

N. diseases: 25
Disease: Multiple Sclerosis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.730 GeneticVariation BEFREE Genome wide association studies have linked a SNP (rs34536443) within <i>TYK2</i> encoding a Proline to Alanine substitution at amino acid 1104, to protection from multiple autoimmune diseases including systemic lupus erythematosus (SLE) and multiple sclerosis (MS). 30740104 2019
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.730 GeneticVariation GWASCAT Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis. 24076602 2013
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.730 GeneticVariation BEFREE These findings suggest that the rs34536443 variant effect on multiple sclerosis susceptibility might be mediated by deviating T lymphocyte differentiation toward a Th2 phenotype. 21354972 2011
Multiple Sclerosis
CUI: C0026769
Disease: Multiple Sclerosis
0.730 GeneticVariation BEFREE A rare functional variant within the TYK2 gene (rs34536443) has been reported as protective in multiple sclerosis (MS) in recent studies. 19888296 2010