rs34612342, MUTYH

N. diseases: 32
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Adenoma
CUI: C0001430
Disease: Adenoma
0.030 GeneticVariation BEFREE A multivariable model showed positive correlation between G396D, Y179C and 1186 ins GG mutations and number of adenomas (OR 8.6, 10.2 and 14.4, respectively). 25822476 2015
Adenoma
CUI: C0001430
Disease: Adenoma
0.030 GeneticVariation BEFREE Two MUTYH mutations, G396D and Y179C, were studied in 1,413 individuals, with MUTYH sequence analysis in 46 cases with CRC in a sibling or adenoma. 22371070 2012
Adenoma
CUI: C0001430
Disease: Adenoma
0.030 GeneticVariation BEFREE Fourteen years of colonoscopic surveillance of an MAP patient (compound heterozygous p.Y165C/p.G382D) showed that adenoma development was slow after initial diagnosis of a single colorectal carcinoma at the age of 44, but then the annual number of new adenomas increased substantially in the patient's early fifties. 19672709 2010