rs34637584, LRRK2

N. diseases: 78
Disease: Hyperactive behavior ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.020 GeneticVariation BEFREE To decipher the biological functions of LRRK2, including the genes and pathways modulated by LRRK2 kinase activity in vivo, we assayed genome-wide mRNA expression in the brain and peripheral tissues from LRRK2 knockout (KO) and kinase hyperactive G2019S (G2019S) transgenic mice. 21972245 2012
Hyperactive behavior
CUI: C0424295
Disease: Hyperactive behavior
0.020 GeneticVariation BEFREE Further, in dopaminergic neurons derived from LRRK2 G2019S PD patient-induced pluripotent stem cells, we demonstrated that either P110 treatment or expression of Drp1(T595A) reduced mitochondrial impairment, lysosomal hyperactivity and neurite shortening. 23813973 2013