rs34637584, LRRK2

N. diseases: 78
Disease: Cognition Disorders ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Cognition Disorders
CUI: C0009241
Disease: Cognition Disorders
0.020 GeneticVariation BEFREE The objective of this study was to determine whether human LRRK2 with G2019S mutation causes hippocampus-dependent cognitive deficits in mice. 28487191 2017
Cognition Disorders
CUI: C0009241
Disease: Cognition Disorders
0.020 GeneticVariation BEFREE Contrastingly, high levels of human LRRK2 cause locomotor alterations and cognitive deficits accompanied by reduced striatal dopamine levels, with the latter also observed in G2019S mutant mice. 26282470 2015