|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In conclusion, the LRRK2 G2385R</span> genotype may not be associated with cognitive dysfunction in PD.
|
27839916 |
2017 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
GWASCAT |
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.
|
22438815 |
2012 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our study indicates that the LRRK2 Gly2385Arg variant is a potential ethnic-specific genetic risk factor of Parkinson's disease within Chinese Han ethnicity.
|
17960808 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A common LRRK2 Gly2385Arg variant has been widely shown to be associated with a two fold increased risk of PD in various Asian populations.
|
18316234 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Generation of 2 induced pluripotent stem cell lines derived from patients with Parkinson's disease carrying LRRK2 G2385R variant.
|
29414410 |
2018 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
LRRK2 Gly2385Arg variant is a risk factor of Parkinson's disease among Han-Chinese from mainland China.
|
18201193 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results suggest that the LRRK2 G2385R variants contribute to the susceptibility of PD especially in Chinese PD.
|
25027012 |
2014 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Although the changes Gly2019Ser and Gly2385Arg of LRRK2 are associated with PD in different populations; they may be a rare cause of PD in our population.
|
24729340 |
2014 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We conclude that the Gly2385Arg variant is not associated with primary dystonia in Taiwan, supporting the specificity of the association between this variant and PD.
|
18450497 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Recently, G2385R substitution in LRRK2 has been determined as a susceptibility allele in Asian PD.
|
18704525 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
However, the coexistence of MAPT IVS1+124C>G significantly enhanced the LRRK2 G2385R-conferred risk for PD (Odds ratio, 2.30; 95% confidence intervals, 1.14-4.54; p = 0.012).
|
24559644 |
2014 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
We found that Rep1, rs356165, and rs11931074 in SNCA gene; G2385R in LRRK2 gene; rs4698412 in BST1 gene; rs1564282 in PARK17; and L444P in GBA gene were associated with PD with adjustment of sex and age (p < 0.05) in the analysis of 16 variants.
|
25623333 |
2015 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These data suggest that the G2385R variant contributes significantly to the etiology of PD in ethnic Han Chinese individuals.
|
17187665 |
2006 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
LRRK2 p.G2385R variant (odds ratio [OR] = 3.2; 95% confidence interval [CI] = 1.96-5.15, p < 0.0001), not BDNF p.V66M alone significantly increased the risk of PD.
|
21924942 |
2012 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The clinical phenotypes and [(18)F]-dopa PET findings for subjects with R1441H or G2385R resembled those of patients with idiopathic PD; however, their lymphoblastoid cell lines showed increased apoptosis following exposure to a proteosome inhibitor.
|
18523869 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Leucine-rich repeat kinase 2 G2385R variant is a risk factor for Parkinson disease in Asian population.
|
17314670 |
2007 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
One hundred and eighty-six participants were enrolled, comprising 43 PD patients without (iPD) and 25 with (LRRK2-PD) the LRRK2 G2385R variant, and 118 healthy controls.
|
27699718 |
2016 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
These findings provide the necessary preliminary data to better understand the unique profile of PD G2385R variant carriers.
|
24046064 |
2013 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
After adjustment for demographics and associated clinical factors, the G2385R variant was associated with an increased risk for the presence of fatigue (OR = 10.699; 95% CI = 2.387-47.958; p = 0.002) in the PD population in this study.
|
28941828 |
2017 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
In this study, we have investigated motor and non-motor aspects in 1638 Chinese PD patients who carried LRRK2 G2385R or R1628P (LRRK2-PD, n = 223), GBA L444P variant (GBA-PD, n = 49), or none of the variants (idiopathic PD [IPD], n = 1366).
|
24095219 |
2014 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Leucine-rich repeat kinase 2 (LRRK2) has been recently identified as a causative gene of Parkinson's disease (PD), and the LRRK2 R1628P and G2385R mutations are common in ethnic Han-Chinese PD patients.
|
29567424 |
2018 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Studies on various global populations have determined that mutations such as G2019S, G2385R, and R1628P in LRRK2 increase the risk of developing PD while the N551K-R1398H haplotype is associated with conferring protection against developing PD.
|
31487119 |
2019 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
The frequency of LRRK2 Gly2385Arg mutation in Hong Kong Chinese with early-onset (age < or =45 years) Parkinson's disease was identified and compared with late-onset patients (age >50 years) and controls.
|
18523722 |
2008 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Two polymorphic variants found almost exclusively among Asians (G2385R and R1628P) have been shown to increase the Parkinson's disease risk by approximately two-fold.
|
19804413 |
2009 |
|
Parkinson Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
G2019S variant is rare in Asian populations, whereas two other Asian-specific LRRK2 variants, G2385R and R1628P, are more frequent with a twofold increased risk of PD.
|
31041581 |
2019 |