Disease | Risk Allele | Score vda | Association Type | Original DB | Sentence supporting the association | PMID | PMID Year | ||||
---|---|---|---|---|---|---|---|---|---|---|---|
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | A gly(388)arg polymorphism (rs351855) in the transmembrane domain of the fibroblast growth factor receptor (FGFR4) is associated with increased risk, staging, and metastasis in several different types of cancer. | 22971346 | 2012 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | These results provide evidence of a role for the FGFR4 Gly388Arg polymorphism in modulating patients' outcome in different types of cancer, thus offering to clinicians a new marker to predict predisposition to poor survival in cancer patients. | 21412156 | 2011 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | The rs351855 G>A polymorphism was associated with an increased cancer risk under the recessive model (OR=1.19, 95% CI=1.01-1.41). | 28445975 | 2017 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | These results suggest that FGFR4 rs351855G/A polymorphism is associated with increased susceptibility to NHL and could be used as a marker for predicting the prognosis of the malignancy. | 24248544 | 2014 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | Our results suggest that the FGFR4 Gly388Arg polymorphism is not a risk factor for GC cancer initiation but that it is a useful prognostic marker for GC patients when the tumor is relatively small, well differentiated, or at an early clinical stage. | 23901234 | 2013 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | The FGFR4 Gly388Arg polymorphism is associated with cancer and cardiovascular diseases, but its association with hypertension is unclear. | 28650667 | 2017 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | Our meta-analysis suggests that the FGFR4 Gly388Arg polymorphism most likely contributes to susceptibility to cancer, especially in Asians. | 20638838 | 2010 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | The Gly388Arg polymorphism in the fibroblast growth factor receptor 4 (FGFR4) gene has been reported to influence prognosis in a wide variety of cancer types. | 17519899 | 2007 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | Clinical investigations of an FGFR4 germline polymorphism, resulting in substitution of glycine by arginine at codon 388 (G388 to R388), have shown a correlation between FGFR4 R388 and aggressive disease progression in cancer patients. | 16109476 | 2006 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | The Gly388Arg polymorphism in the FGFR4 gene was reported to modulate cancer cell migration in vitro and to be associated with breast, colon, and prostate cancer prognostic parameters. | 16061909 | 2005 | |||||
Primary malignant neoplasm
|
0.100 | GeneticVariation | BEFREE | Thus, our findings elucidate the molecular mechanism behind the genetic association of rs351855 with accelerated cancer progression and suggest that germline variants of cell-surface molecules that recruit STAT3 to the inner cell membrane are a significant risk for cancer prognosis and disease progression. | 26675719 | 2015 |