|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We did not observe any association between TLR9 polymorphisms (rs187084, rs352140, rs5743836 and rs352139) and SLE under any model, after excluding the data that were inconsistent with Hardy-Weinberg equilibrium (HWE).
|
28528372 |
2017 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
We studied the distribution of the TLR9 rs352139 (G + 1174A) single nucleotide polymorphism (SNP) by allele-specific polymerase chain reaction (PCR) in 104 Egyptian patients with SLE and 108 age-, sex-, and ethnically matched controls.
|
27018624 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
The meta-analysis showed no association between the two alleles of the rs352140, rs5743836, and rs352139 polymorphisms of TLR9 and SLE, but indicated an association between the two alleles of the rs187084 polymorphism (TLR9) and SLE in the overall population (OR = 0.869, 95% CI = 0.762-0.992, P = 0.038).
|
26762473 |
2016 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
The meta-analysis indicated that rs352139 polymorphism might be associated with decreased TB risk in Indonesians whereas increased risk in Mexicans.
|
25948535 |
2015 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
An increased risk of TB was found for individuals with the TLR2 rs3804100 CC and the TLR9 rs352139 GA and GG genotypes, while decreased risk was identified for those with the AG genotype of TLR1 rs4833095.
|
26430737 |
2015 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Our study suggests that the allele A of the intronic polymorphism rs352139 on TLR9 gene might contribute to the risk of developing TB in Mexican Amerindians.
|
24053111 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.040 |
GeneticVariation
|
BEFREE |
In conclusion, there is still not enough evidence to indicate an association between TLR9 gene rs187084, rs352139, and rs352140 polymorphisms and the development of SLE in the Asian population.
|
22228476 |
2012 |
|
Tuberculosis
|
|
0.040 |
GeneticVariation
|
BEFREE |
Meta-analysis of the Indonesian and Vietnamese populations showed that rs352139 was significantly associated with TB in the recessive model.
|
22211722 |
2012 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
Polymorphisms rs3804099 (TLR2) and rs352139 (TLR9) may also be associated with PTB risk in the Moldavian population but their effect is less consistent across different studies.
|
30529560 |
2019 |
|
Tuberculosis, Pulmonary
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, for TLR4 rs4986791, a significant increased PTB risk was found in Africans, and for TLR9 rs352139 a significant increased PTB </span>risk was found in Asians after subgroup analysis by ethnicity, although the enrolled studies were limited.
|
25889916 |
2015 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Crohn Disease
|
|
0.020 |
GeneticVariation
|
BEFREE |
The polymorphisms TLR2 (rs1816702), NFKB1 (rs28362491), TNFRSF1A (rs4149570), IL6R (rs4537545), IL23R (rs11209026) and PTPN22 (rs2476601) were associated with risk of CD and the polymorphisms TLR2 (rs1816702), TLR4 (rs1554973 and rs12377632), TLR9 (rs352139), LY96 (rs11465996), NFKBIA (rs696), TNFA (rs1800629), TNFRSF1A (rs4149570), IL10 (rs3024505), IL23R (rs11209026), PTPN22 (rs2476601) and PPARG (rs1801282) were associated with risk of UC.
|
24971461 |
2014 |
|
Ulcerative Colitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Nineteen functional polymorphisms that alter the NFκB-mediated inflammatory response (TLR2 (rs3804099, rs11938228, rs1816702, rs4696480), TLR4 (rs5030728, rs1554973), TLR9 (rs187084, rs352139), LY96 (MD-2) (rs11465996), CD14 (rs2569190), MAP3K14 (NIK) (rs7222094)), TNF-α signaling (TNFA (TNF-α) (rs361525), TNFRSF1A (TNFR1) (rs4149570), TNFAIP3(A20) (rs6927172)) and other cytokines regulated by NFκB (IL1B (rs4848306), IL1RN (rs4251961), IL6 (rs10499563), IL17A (rs2275913), IFNG (rs2430561)) were associated with response to anti-TNF therapy among patients with CD, UC or both CD and UC (P ⩽ 0.05).
|
24776844 |
2014 |
|
Hepatitis A
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1898830, rs1879026, rs187084 and rs352139 were also demonstrated to modulate the prognosis [ie, aspartate aminotransferase (AST)/alanine transaminase (ALT)>1.5] of newborns with severe hepatitis (all P<.05).
|
28703296 |
2018 |
|
Hepatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, rs1898830, rs1879026, rs187084 and rs352139 were also demonstrated to modulate the prognosis [ie, aspartate aminotransferase (AST)/alanine transaminase (ALT)>1.5] of newborns with severe hepatitis (all P<.05).
|
28703296 |
2018 |
|
Colon Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>TLR-9</i> rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.
|
28031717 |
2017 |
|
Seizures
|
|
0.010 |
GeneticVariation
|
BEFREE |
For TLR9 rs352139, patients who carried genotype AA and minor allele A developed seizures less often than those without (OR = 0.289, p = 0.003 and OR = 0.568, p = 0.004, respectively).
|
28202935 |
2017 |
|
Neoplasms
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>TLR-9</i> rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.
|
28031717 |
2017 |
|
Malignant tumor of colon
|
|
0.010 |
GeneticVariation
|
BEFREE |
The <i>TLR-9</i> rs352139 and rs352144 SNPs were significantly associated with colon cancer development when the tumor was located in the rectal area.
|
28031717 |
2017 |
|
Meningitis, Bacterial
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 (rs3804099), TLR3 (rs3775291 and rs3775290) and TLR9 (rs352139 and rs352140).
|
28202935 |
2017 |
|
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
The rs352139 GG genotype showed a significantly reduced relative risk for HCMV infection (Pc = 0.006).
|
27105145 |
2016 |
|
Inflammatory Bowel Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Meta-analyses showed that polymorphisms in TLR2 (rs3804099, OR (95% CI) = 2.17 (1.35-3.47)], rs11938228 [OR = 0.64 (0.43-0.96)], TLR4 (rs5030728) [OR = 3.18 (1.63-6.21)], TLR9 (rs352139) [OR = 0.43 (0.21-0.88)], TNFRSF1A (rs4149570) [OR = 2.06 (1.02-4.17)], IFNG (rs2430561) [OR = 1.66 (1.05-2.63)], IL6 (rs10499563) [OR = 1.65 (1.04-2.63)] and IL1B (rs4848306) [OR = 1.88 (1.05-3.35)] were significantly associated with response among IBD patients using clinical response criteria.
|
27417569 |
2016 |
|
Acute GVH disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found that two tagSNPs in the TLR9 gene in the donor side, +1174 A/G (rs352139) and +1635 C/T (rs352140), influenced the risk of acute GVHD (aGVHD) and CMV reactivation.
|
24121213 |
2014 |
|
Membranous glomerulonephritis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The result suggests for the first time that TLR9 (rs352139 and rs352140) polymorphisms may contribute to the development and progression of MGN.
|
23964786 |
2013 |