rs35677470, DNASE1L3

N. diseases: 6
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.800 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.800 GeneticVariation GWASCAT High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Rheumatoid Arthritis
CUI: C0003873
Disease: Rheumatoid Arthritis
0.800 GeneticVariation GWASDB High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis. 23143596 2012
Systemic Scleroderma
CUI: C0036421
Disease: Systemic Scleroderma
0.710 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Systemic Scleroderma
CUI: C0036421
Disease: Systemic Scleroderma
0.710 GeneticVariation GWASCAT Transethnic meta-analysis identifies GSDMA and PRDM1 as susceptibility genes to systemic sclerosis. 28314753 2017
Systemic Scleroderma
CUI: C0036421
Disease: Systemic Scleroderma
0.710 GeneticVariation GWASCAT Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. 24387989 2014
Systemic Scleroderma
CUI: C0036421
Disease: Systemic Scleroderma
0.710 GeneticVariation BEFREE This study identified a likely functional variant influencing scleroderma susceptibility at the DNASE1L3 locus; a missense polymorphism rs35677470 in DNASE1L3, with an odds ratio of 2.35 (P = 2.3 × 10(-10)) in anti-centromere antibody (ACA) positive cases. 25332064 2014
Lupus Erythematosus, Systemic
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Myositis
CUI: C0027121
Disease: Myositis
0.700 GeneticVariation GWASCAT Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases. 30573655 2019
Scleroderma, Limited
CUI: C0748540
Disease: Scleroderma, Limited
0.700 GeneticVariation GWASCAT Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. 24387989 2014
Scleroderma
CUI: C0011644
Disease: Scleroderma
0.010 GeneticVariation BEFREE This study identified a likely functional variant influencing scleroderma susceptibility at the DNASE1L3 locus; a missense polymorphism rs35677470 in DNASE1L3, with an odds ratio of 2.35 (P = 2.3 × 10(-10)) in anti-centromere antibody (ACA) positive cases. 25332064 2014