rs3736228, LRP5

N. diseases: 13
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE All of the functional evidence suggested the important functional mechanisms underlying the associations of the 2 SNPs (rs2278729 and rs3736228) and 3 genes (RPL31, CPT1A and MTL5) with osteoporosis. 28369098 2017
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE With regard to genetic factors, low-density lipoprotein receptor-related protein 5 (LRP5) A1330V is known to be associated with osteoporosis in the general population, but the influence of this polymorphism in COPD is unknown. 25392953 2015
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE Results identified that carriers of rs3736228 C>T variant in the LRP5 gene were associated with an increased risk of developing osteoporosis and fractures under 4 genetic models but not under the dominant model (OR = 1.19, 95% CI = 0.97~1.46, and P = 0.103). 25580429 2014
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE The A1330V polymorphism of LRP5 is possibly correlated with response to alendronate treatment in Chinese women with osteoporosis, and the TT genotype could possibly predict a weak response to alendronate. 24897288 2014
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE In this study were determined the allelic and genotypic frequencies of four polymorphic markers (C/T rs3736228, G/A rs4988321, T/C rs627174 and T/C rs901824) in the low-density lipoprotein receptor-related protein 5 gene (LRP5) and their association with osteoporosis in 100 pos-menopausal osteoporotic Mexican women and their controls, using real time-PCR and TaqMan probes. 23242660 2013
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE Investigation of LRP5 A1330V polymorphism may be useful for identifying individuals who are susceptible to osteoporosis, allowing early preventive measures to be provided. 21147715 2010
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE These data suggest that the A1330V variation in the LRP5 gene may affect the pathogenesis of osteoporosis. 19571442 2009
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE A non-synonymous SNP in the LRP5 gene was associated with decreased bone mineral density (rs3736228, p=6.3x10(-12) for lumbar spine and p=1.9x10(-4) for femoral neck) and an increased risk of both osteoporotic fractures (odds ratio [OR] 1.3, 95% CI 1.09-1.52, p=0.002) and osteoporosis (OR 1.3, 1.08-1.63, p=0.008). 18455228 2008
Osteoporosis
CUI: C0029456
Disease: Osteoporosis
0.090 GeneticVariation BEFREE Genotypes and haplotypes were based on LRP5 missense substitutions in exons 9 (c.2047G > A, p.V667M) and 18 (c.4037C > T, p.A1330V), and their association with osteoporosis evaluated after adjustment for multiple clinical and environmental variables using logistic regression. 16168727 2005