Ventricular arrhythmia
|
|
0.050 |
GeneticVariation
|
BEFREE |
A human genetic variant (Ser96Ala) in the sarcoplasmic reticulum (SR) histidine-rich Ca(2+)-binding (HRC) protein has been linked to ventricular arrhythmia and sudden death in dilated cardiomyopathy.
|
24125847 |
2013 |
Cardiac Arrhythmia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Abnormal calcium cycling and cardiac arrhythmias associated with the human Ser96Ala genetic variant of histidine-rich calcium-binding protein.
|
24125847 |
2013 |
Cardiac Arrhythmia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Herein, we summarize the current evidence on the pivotal role of HRC in the regulation of cardiac rhythmicity and the importance of HRC Ser96Ala as a genetic modifier for arrhythmias in the setting of heart failure.
|
30319456 |
2018 |
Heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Herein, we summarize the current evidence on the pivotal role of HRC in the regulation of cardiac rhythmicity and the importance of HRC Ser96Ala as a genetic modifier for arrhythmias in the setting of heart failure.
|
30319456 |
2018 |
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
Herein, we summarize the current evidence on the pivotal role of HRC in the regulation of cardiac rhythmicity and the importance of HRC Ser96Ala as a genetic modifier for arrhythmias in the setting of heart failure.
|
30319456 |
2018 |
Heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, expression of the HRC(S96A) genetic variant in cardiomyocytes from a rat model of postmyocardial infarction heart failure induced dramatic disturbances of rhythmic Ca(2+) transients.
|
21742996 |
2011 |
Congestive heart failure
|
|
0.020 |
GeneticVariation
|
BEFREE |
However, expression of the HRC(S96A) genetic variant in cardiomyocytes from a rat model of postmyocardial infarction heart failure induced dramatic disturbances of rhythmic Ca(2+) transients.
|
21742996 |
2011 |
Atrial Fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
HRC SNP Ser96Ala is important as a new genetic marker of AF recurrence after RFCA.
|
30840693 |
2019 |
Cardiac Arrhythmia
|
|
0.040 |
GeneticVariation
|
BEFREE |
Impaired calcium homeostasis is associated with sudden cardiac death and arrhythmias in a genetic equivalent mouse model of the human HRC-Ser96Ala variant.
|
28859293 |
2017 |
Cardiac Arrhythmia
|
|
0.040 |
GeneticVariation
|
BEFREE |
In the present study, we assessed the molecular and cellular mechanisms underlying human arrhythmias by adenoviral expression of the human wild-type (HRC(WT)) or mutant HRC (HRC(S96A)) in adult rat ventricular cardiomyocytes.
|
21742996 |
2011 |
Ventricular arrhythmia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
|
18617481 |
2008 |
Cardiomyopathy, Familial Idiopathic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Ser96Ala genetic variant of HRC is associated with life-threatening ventricular arrhythmias in idiopathic DCM and may serve as an independent predictor of susceptibility to arrhythmogenesis in the setting of DCM.
|
18617481 |
2008 |
Ventricular arrhythmia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The common Ser96Ala human genetic variant of HRC strongly correlates with life-threatening ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy.
|
28784772 |
2017 |
Cardiomyopathy, Familial Idiopathic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The common Ser96Ala human genetic variant of HRC strongly correlates with life-threatening ventricular arrhythmias in patients with idiopathic dilated cardiomyopathy.
|
28784772 |
2017 |
Ventricular arrhythmia
|
|
0.050 |
GeneticVariation
|
BEFREE |
The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy.
|
28859293 |
2017 |
Cardiomyopathy, Familial Idiopathic
|
|
0.030 |
GeneticVariation
|
BEFREE |
The histidine-rich calcium-binding protein (HRC) Ser96Ala variant has previously been identified as a potential biomarker for ventricular arrhythmias and sudden cardiac death in patients with idiopathic dilated cardiomyopathy.
|
28859293 |
2017 |
Diabetes
|
|
0.010 |
GeneticVariation
|
BEFREE |
The patient age was younger and rate of diabetes and hypertension lower in the PAF patients with Ser96Ala than in those without (TT/TG/GG, 179/120/35; 64±10/60±12/59±13 y, P = 0.001; 18.5/ 9.2/8.6%, P = 0.04 and 66.1/50.0/37.1%, P = 0.001, respectively).
|
30840693 |
2019 |
Diabetes Mellitus
|
|
0.010 |
GeneticVariation
|
BEFREE |
The patient age was younger and rate of diabetes and hypertension lower in the PAF patients with Ser96Ala than in those without (TT/TG/GG, 179/120/35; 64±10/60±12/59±13 y, P = 0.001; 18.5/ 9.2/8.6%, P = 0.04 and 66.1/50.0/37.1%, P = 0.001, respectively).
|
30840693 |
2019 |
Hypertensive disease
|
|
0.010 |
GeneticVariation
|
BEFREE |
The patient age was younger and rate of diabetes and hypertension lower in the PAF patients with Ser96Ala than in those without (TT/TG/GG, 179/120/35; 64±10/60±12/59±13 y, P = 0.001; 18.5/ 9.2/8.6%, P = 0.04 and 66.1/50.0/37.1%, P = 0.001, respectively).
|
30840693 |
2019 |
Ventricular arrhythmia
|
|
0.050 |
GeneticVariation
|
BEFREE |
These findings indicate that the HRC Ser96Ala variant increases the propensity of arrhythmogenic Ca(2+) waves in the stressed failing heart, suggesting a link between this genetic variant and life-threatening ventricular arrhythmias in human carriers.
|
21742996 |
2011 |
Paroxysmal atrial fibrillation
|
|
0.010 |
GeneticVariation
|
BEFREE |
We enrolled PAF patients who underwent RFCA (N = 334 for screening and N = 245 for replication) and were genotyped for HRC SNP (rs3745297).
|
30840693 |
2019 |