rs3749171, GPR35

N. diseases: 9
Disease: Primary sclerosing cholangitis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Primary sclerosing cholangitis
CUI: C0566602
Disease: Primary sclerosing cholangitis
0.020 GeneticVariation BEFREE The T108M polymorphism is associated with ulcerative colitis and primary sclerosing cholangitis, inflammatory diseases with a high cancer risk. 30600262 2019
Primary sclerosing cholangitis
CUI: C0566602
Disease: Primary sclerosing cholangitis
0.020 GeneticVariation BEFREE We discovered novel genome-wide significant associations with PSC at 2q37 [rs3749171 at G-protein-coupled receptor 35 (GPR35); P = 3.0 × 10(-9) in the overall study population, combined odds ratio [OR] and 95% confidence interval [CI] of 1.39 (1.24-1.55)] and at 18q21 [rs1452787 at transcription factor 4 (TCF4); P = 2.61 × 10(-8) , OR (95% CI) = 0.75 (0.68-0.83)]. 22821403 2013