|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There appears to be a possible association between the TLR3 missense mutation rs3775291 and multiple sclerosis, which might be attributed to changes in the TLR3 functional properties.
|
31177052 |
2019 |
|
Congenital Zika syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148).
|
31352487 |
2019 |
|
Zika Virus Infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148).
|
31352487 |
2019 |
|
Microcephaly
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene.
|
31352487 |
2019 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751.
|
29259020 |
2018 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection.
|
30143709 |
2018 |
|
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 A allele was associated with a reduced likelihood of spontaneous HBsAg SC and HBeAg SC, and an increased risk of developing chronic hepatitis B.
|
30143709 |
2018 |
|
Sarcoidosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and reveals TLR3 L412F as a candidate biomarker.
|
29237089 |
2018 |
|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |
|
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms rs3775291, rs5743305 (associated with TLR3 expression), and rs755622 (associated with MIF expression) were assessed in blood samples from 108 TBE patients and 72 non-TBE controls.
|
28646884 |
2017 |
|
Meningitis, Bacterial
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 (rs3804099), TLR3 (rs3775291 and rs3775290) and TLR9 (rs352139 and rs352140).
|
28202935 |
2017 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes.
|
28592890 |
2017 |
|
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an increased frequency of the heterozygous genotype TLR3 L412F in children with HCMV infection compared with uninfected cases.
|
28046022 |
2017 |
|
Liver carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study revealed that TLR2 rs3804100 and TLR3 rs3775291 polymorphisms may be protective factors for HBV-related HCC.
|
28009434 |
2017 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT).
|
25992926 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]).
|
27227908 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed donor age older than 40 yr (OR=2.93; 95% CI = 1.49-5.8, p = 0.002) and the TLR3 Leu412Phe CC genotype (OR=2.02, 95%CI=1.01-4.05, p = 0.046) were independently associated with severe HCV recurrence.
|
27101936 |
2016 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Stratification analysis by ethnicity indicated that rs3775291 was associated with all forms of AMD, GA and nAMD only in Caucasians (OR = 0.87, 0.78 and 0.77, respectively, for the TT genotype) but not in East Asians.
|
26796995 |
2016 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values.
|
26796995 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population.
|
26318769 |
2016 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
No associations were found between rs5744168 (TLR5), rs4986791 (TLR4), rs4986790 (TLR4), and rs3775291 (TLR3) polymorphisms and SLE susceptibility.
|
26762473 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
|
25766991 |
2015 |
|
Japanese Encephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of Leu412Phe polymorphism was noted in JE patients as compared with healthy controls [mutant (TT) genotype, P-value=0.019; mutant (TT)+heterozygous (CT) genotype, P-value=0.013].
|
26298326 |
2015 |
|
Pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015).
|
25423559 |
2015 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |