rs3775291, TLR3

N. diseases: 51
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Acute-On-Chronic Liver Failure
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751. 29259020 2018
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined. 19628747 2009
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations. 21079408 2011
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent. 18753640 2008
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing. 18385087 2008
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Stratification analysis by ethnicity indicated that rs3775291 was associated with all forms of AMD, GA and nAMD only in Caucasians (OR = 0.87, 0.78 and 0.77, respectively, for the TT genotype) but not in East Asians. 26796995 2016
Asthma
CUI: C0004096
Disease: Asthma
0.010 GeneticVariation BEFREE We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes. 28592890 2017
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.010 GeneticVariation BEFREE We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity. 22024499 2012
Bacterial Infections
CUI: C0004623
Disease: Bacterial Infections
0.010 GeneticVariation BEFREE Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity. 22024499 2012
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.010 GeneticVariation BEFREE In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population. 26226228 2015
Bronchiolitis
CUI: C0006271
Disease: Bronchiolitis
0.010 GeneticVariation BEFREE Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing. 22549436 2012
Chronic candidiasis
CUI: C0857069
Disease: Chronic candidiasis
0.010 GeneticVariation BEFREE We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity. 22024499 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.010 GeneticVariation BEFREE More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events). 21239167 2011
Complete atrioventricular block
CUI: C0151517
Disease: Complete atrioventricular block
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Congenital Zika syndrome
CUI: C4552332
Disease: Congenital Zika syndrome
0.010 GeneticVariation BEFREE This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148). 31352487 2019
Cutaneous Candidiasis
CUI: C0006846
Disease: Cutaneous Candidiasis
0.010 GeneticVariation BEFREE The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. 22024499 2012
Cytomegalovirus Infections
CUI: C0010823
Disease: Cytomegalovirus Infections
0.010 GeneticVariation BEFREE We found an increased frequency of the heterozygous genotype TLR3 L412F in children with HCMV infection compared with uninfected cases. 28046022 2017
Dengue Fever
CUI: C0011311
Disease: Dengue Fever
0.010 GeneticVariation BEFREE Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. 25446400 2015
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population. 26318769 2016
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control. 24408902 2014
Drug usage
CUI: C0242510
Disease: Drug usage
0.010 GeneticVariation BEFREE We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity. 22174453 2012
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005). 18753640 2008
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values. 26796995 2016
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. 21712495 2011