Acute-On-Chronic Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751.
|
29259020 |
2018 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations.
|
21079408 |
2011 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent.
|
18753640 |
2008 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing.
|
18385087 |
2008 |
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Stratification analysis by ethnicity indicated that rs3775291 was associated with all forms of AMD, GA and nAMD only in Caucasians (OR = 0.87, 0.78 and 0.77, respectively, for the TT genotype) but not in East Asians.
|
26796995 |
2016 |
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes.
|
28592890 |
2017 |
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
Chronic candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events).
|
21239167 |
2011 |
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
Congenital Zika syndrome
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study shows that rs3775291 SNP at Toll-like receptor 3, which triggers type I interferon antiviral responses in mothers infected by Zika virus during pregnancy, is associated with CZS occurrence (odds ratio [OR], 2.19; 95% confidence interval [CI], 1.158-4.148).
|
31352487 |
2019 |
Cutaneous Candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
|
22024499 |
2012 |
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an increased frequency of the heterozygous genotype TLR3 L412F in children with HCMV infection compared with uninfected cases.
|
28046022 |
2017 |
Dengue Fever
|
|
0.010 |
GeneticVariation
|
BEFREE |
Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF.
|
25446400 |
2015 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population.
|
26318769 |
2016 |
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control.
|
24408902 |
2014 |
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005).
|
18753640 |
2008 |
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values.
|
26796995 |
2016 |
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.
|
21712495 |
2011 |