rs3775291, TLR3

N. diseases: 51
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE This study analyzed epidemiological and clinical data from a total of 137 patients with chronic HCV infection with regard to two polymorphic positions within the TLR3 gene: rs5743305 (T/A) is located within the promoter region and might affect transcriptional activity, rs3775291 (C/T) is a non-synonymous single nucleotide polymorphism (SNP) located within exon 4 and the variant receptor has been shown to be functionally impaired. 19475618 2009
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity. 22174453 2012
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE TLR3 L412F is significantly common in HCV-infected liver recipients, and may be associated with worse outcomes. 23240626 2013
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients. 25766991 2015
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT). 25992926 2016
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE Multivariate analysis showed donor age older than 40 yr (OR=2.93; 95% CI = 1.49-5.8, p = 0.002) and the TLR3 Leu412Phe CC genotype (OR=2.02, 95%CI=1.01-4.05, p = 0.046) were independently associated with severe HCV recurrence. 27101936 2016
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.070 GeneticVariation BEFREE Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]). 27227908 2016
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing. 18385087 2008
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent. 18753640 2008
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined. 19628747 2009
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations. 21079408 2011
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE Stratification analysis by ethnicity indicated that rs3775291 was associated with all forms of AMD, GA and nAMD only in Caucasians (OR = 0.87, 0.78 and 0.77, respectively, for the TT genotype) but not in East Asians. 26796995 2016
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.060 GeneticVariation BEFREE We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751. 29259020 2018
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005). 18753640 2008
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. 21712495 2011
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values. 26796995 2016
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control. 24408902 2014
Diabetes Mellitus, Insulin-Dependent
0.020 GeneticVariation BEFREE We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population. 26318769 2016
Tick-Borne Encephalitis
CUI: C0014061
Disease: Tick-Borne Encephalitis
0.020 GeneticVariation BEFREE These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population. 23721942 2013
Tick-Borne Encephalitis
CUI: C0014061
Disease: Tick-Borne Encephalitis
0.020 GeneticVariation BEFREE Single nucleotide polymorphisms rs3775291, rs5743305 (associated with TLR3 expression), and rs755622 (associated with MIF expression) were assessed in blood samples from 108 TBE patients and 72 non-TBE controls. 28646884 2017
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.020 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.020 GeneticVariation BEFREE In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection. 30143709 2018
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.020 GeneticVariation BEFREE Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls. 23076446 2013
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.020 GeneticVariation BEFREE The TLR3 rs3775291 A allele was associated with a reduced likelihood of spontaneous HBsAg SC and HBeAg SC, and an increased risk of developing chronic hepatitis B. 30143709 2018
Asthma
CUI: C0004096
Disease: Asthma
0.010 GeneticVariation BEFREE We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes. 28592890 2017