|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Samples collected from HCV (n = 74) and HBV (n = 35) carriers were subjected to quantitative real-time PCR (qPCR) to detect the presence of the SNPs rs5743305 and rs3775291 in TLR3 and to measure the following biomarkers: alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and prothrombin time (PT).
|
25992926 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Subgroup analyses by a polymorphism site indicated an increased risk of HCV infection in relation to the TT/CT genotypes of rs3775291 (1.50 [1.11-2.01]), and a decreased risk ascribed to the T allele (0.20 [0.16-0.25]).
|
27227908 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study analyzed epidemiological and clinical data from a total of 137 patients with chronic HCV infection with regard to two polymorphic positions within the TLR3 gene: rs5743305 (T/A) is located within the promoter region and might affect transcriptional activity, rs3775291 (C/T) is a non-synonymous single nucleotide polymorphism (SNP) located within exon 4 and the variant receptor has been shown to be functionally impaired.
|
19475618 |
2009 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed donor age older than 40 yr (OR=2.93; 95% CI = 1.49-5.8, p = 0.002) and the TLR3 Leu412Phe CC genotype (OR=2.02, 95%CI=1.01-4.05, p = 0.046) were independently associated with severe HCV recurrence.
|
27101936 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
TLR3 L412F is significantly common in HCV-infected liver recipients, and may be associated with worse outcomes.
|
23240626 |
2013 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
|
25766991 |
2015 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We found no associations of <i>TLR3</i> (rs3775291), <i>CFD</i> (rs3826945), <i>FRK</i> (rs1999930) or <i>LIPC</i> (rs10468017) or <i>APOE</i> ε4 alleles with nvAMD or early AMD, nor between early AMD and rs1883025 or rs4711751.
|
29259020 |
2018 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations.
|
21079408 |
2011 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent.
|
18753640 |
2008 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing.
|
18385087 |
2008 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Stratification analysis by ethnicity indicated that rs3775291 was associated with all forms of AMD, GA and nAMD only in Caucasians (OR = 0.87, 0.78 and 0.77, respectively, for the TT genotype) but not in East Asians.
|
26796995 |
2016 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005).
|
18753640 |
2008 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values.
|
26796995 |
2016 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.
|
21712495 |
2011 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection.
|
30143709 |
2018 |
|
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that the G allele (within the G/G homozygous genotype) of the TLR3 rs3775291 SNP is associated with predisposition to TBE in the Russian population.
|
23721942 |
2013 |
|
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 A allele was associated with a reduced likelihood of spontaneous HBsAg SC and HBeAg SC, and an increased risk of developing chronic hepatitis B.
|
30143709 |
2018 |
|
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls.
|
23076446 |
2013 |
|
Tick-Borne Encephalitis
|
|
0.020 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms rs3775291, rs5743305 (associated with TLR3 expression), and rs755622 (associated with MIF expression) were assessed in blood samples from 108 TBE patients and 72 non-TBE controls.
|
28646884 |
2017 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
We investigated the association of the TLR3 variants, rs13126816 and rs3775291, with the autoimmune endocrine disorders, Addison's disease (AD) and type 1 diabetes (T1D) in the Polish population.
|
26318769 |
2016 |
|
Diabetes Mellitus, Insulin-Dependent
|
|
0.020 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control.
|
24408902 |
2014 |
|
Acute-On-Chronic Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |