rs3775291, TLR3

N. diseases: 30
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.010 GeneticVariation BEFREE A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse. 26226228 2016
Malignant neoplasm of breast
CUI: C0006142
Disease: Malignant neoplasm of breast
0.010 GeneticVariation BEFREE A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse. 26226228 2016
Dengue Fever
CUI: C0011311
Disease: Dengue Fever
0.010 GeneticVariation BEFREE Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. 25446400 2015
Severe Dengue
CUI: C0019100
Disease: Severe Dengue
0.010 GeneticVariation BEFREE Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. 25446400 2015
Pancreatitis
CUI: C0030305
Disease: Pancreatitis
0.010 GeneticVariation BEFREE Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015). 25423559 2015
HIV Infections
CUI: C0019693
Disease: HIV Infections
0.010 GeneticVariation BEFREE The TLR3 rs3775291 T allele has a protective effect against HIV infection among HESNs IDUs. 23962581 2014
Myocarditis
CUI: C0027059
Disease: Myocarditis
0.010 GeneticVariation BEFREE A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. 23962581 2014
Hamman-Rich syndrome
CUI: C0085786
Disease: Hamman-Rich syndrome
0.010 GeneticVariation BEFREE The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. 24070541 2014
Diabetes Mellitus, Insulin-Dependent
0.010 GeneticVariation BEFREE The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control. 24408902 2014
Idiopathic Pulmonary Fibrosis
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
0.010 GeneticVariation BEFREE The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. 24070541 2014
Bronchiolitis
CUI: C0006271
Disease: Bronchiolitis
0.010 GeneticVariation BEFREE Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing. 22549436 2013
Acute-On-Chronic Liver Failure
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.010 GeneticVariation BEFREE Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls. 23076446 2013
Complete atrioventricular block
CUI: C0151517
Disease: Complete atrioventricular block
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Wheezing
CUI: C0043144
Disease: Wheezing
0.010 GeneticVariation BEFREE Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing. 22549436 2013
Chronic candidiasis
CUI: C0857069
Disease: Chronic candidiasis
0.010 GeneticVariation BEFREE We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity. 22024499 2012
Virus Diseases
CUI: C0042769
Disease: Virus Diseases
0.010 GeneticVariation BEFREE Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility. 22174453 2012
Autoimmune Diseases
CUI: C0004364
Disease: Autoimmune Diseases
0.010 GeneticVariation BEFREE The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. 22024499 2012
Cutaneous Candidiasis
CUI: C0006846
Disease: Cutaneous Candidiasis
0.010 GeneticVariation BEFREE The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity. 22024499 2012
Bacterial Infections
CUI: C0004623
Disease: Bacterial Infections
0.010 GeneticVariation BEFREE Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity. 22024499 2012
Hepatitis C
CUI: C0019196
Disease: Hepatitis C
0.010 GeneticVariation BEFREE We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity. 22174453 2012
Drug usage
CUI: C0242510
Disease: Drug usage
0.010 GeneticVariation BEFREE We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity. 22174453 2012
Non-Small Cell Lung Carcinoma
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
0.010 GeneticVariation BEFREE Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01). 21412764 2012
Colorectal Carcinoma
CUI: C0009402
Disease: Colorectal Carcinoma
0.010 GeneticVariation BEFREE More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events). 21239167 2011