|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing.
|
18385087 |
2008 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent.
|
18753640 |
2008 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005).
|
18753640 |
2008 |
|
Subacute Sclerosing Panencephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The frequency of 412Phe allele of TLR3 rs3775291 in SSPE patients was significantly higher than that in controls (P=.03).
|
19016379 |
2008 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
This study analyzed epidemiological and clinical data from a total of 137 patients with chronic HCV infection with regard to two polymorphic positions within the TLR3 gene: rs5743305 (T/A) is located within the promoter region and might affect transcriptional activity, rs3775291 (C/T) is a non-synonymous single nucleotide polymorphism (SNP) located within exon 4 and the variant receptor has been shown to be functionally impaired.
|
19475618 |
2009 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations.
|
21079408 |
2011 |
|
Polypoidal choroidal vasculopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients.
|
21079408 |
2011 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events).
|
21239167 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
|
21412764 |
2012 |
|
Geographic Atrophy
|
|
0.030 |
GeneticVariation
|
BEFREE |
Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity.
|
21712495 |
2011 |
|
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
|
Cutaneous Candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
|
22024499 |
2012 |
|
Autoimmune Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
|
Chronic candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
We have shown here aberrant biological responses mediated by the TLR3 variant receptor, L412F, which may explain in part susceptibility of patients to chronic candidiasis, viral infections and autoimmunity.
|
22024499 |
2012 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility.
|
22174453 |
2012 |
|
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
Herpes Labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR3 L412F genetic polymorphism was found to reduce NK cell TLR3-responsiveness and is associated with susceptibility to recurrent HL.
|
22537752 |
2012 |
|
Recurrent herpes simplex labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.
|
22537752 |
2012 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Hepatitis B, Chronic
|
|
0.020 |
GeneticVariation
|
BEFREE |
Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls.
|
23076446 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Acute-On-Chronic Liver Failure
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |