|
Myocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
HIV-1 infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
Japanese Encephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of Leu412Phe polymorphism was noted in JE patients as compared with healthy controls [mutant (TT) genotype, P-value=0.019; mutant (TT)+heterozygous (CT) genotype, P-value=0.013].
|
26298326 |
2015 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
A single-nucleotide polymorphism (SNP; rs3775291) in the Toll-like receptor 3 (TLR3) gene has recently been implicated in the pathogenesis of AMD in Caucasian populations.
|
21079408 |
2011 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
|
21412764 |
2012 |
|
Microcephaly
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association Between Zika Virus Microcephaly in Newborns With the rs3775291 Variant in Toll-Like Receptor 3 and rs1799964 Variant at Tumor Necrosis Factor-α Gene.
|
31352487 |
2019 |
|
Recurrent herpes simplex labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Association of TLR3-hyporesponsiveness and functional TLR3 L412F polymorphism with recurrent herpes labialis.
|
22537752 |
2012 |
|
Pseudohyperkalemia Cardiff
|
|
0.010 |
GeneticVariation
|
BEFREE |
Carriage of the C allele in three SNPs of TLR3 (rs3775290, rs3775291, and rs5743312), the C allele in TLR7 (rs3853839) in females only, and the C allele in TLR8 (rs3764879) in males only were significantly higher in SVC group than CHC group (P < 0.001), while carriage of the T allele in TLR7 (rs179008) in females only and the A allele in TLR8 (rs3764880) in both males and females were significantly higher in CHC infection more than SVC group (P < 0.001).
|
29947302 |
2018 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing.
|
18385087 |
2008 |
|
Age related macular degeneration
|
|
0.060 |
GeneticVariation
|
BEFREE |
Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined.
|
19628747 |
2009 |
|
Herpes Labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR3 L412F genetic polymorphism was found to reduce NK cell TLR3-responsiveness and is associated with susceptibility to recurrent HL.
|
22537752 |
2012 |
|
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility.
|
22174453 |
2012 |
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate analysis, TLR3 L412F was significantly associated with chronic hepatitis C (odds ratio: 1.73, 95% confidence interval [CI]: 1.13-2.65, P = 0.01).
|
23240626 |
2013 |
|
Hepatitis B
|
|
0.020 |
GeneticVariation
|
BEFREE |
In our study, we analysed the impact of the TLR3 polymorphisms rs3775291 and rs5743305 on the natural course of HBV infection.
|
30143709 |
2018 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Breast Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Colorectal Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
More importantly, among 582 followed up patients the SNP rs3775291 in the toll-like receptor 3 (TLR-3) gene was associated with CRC specific survival (150 events).
|
21239167 |
2011 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Multivariate analysis showed donor age older than 40 yr (OR=2.93; 95% CI = 1.49-5.8, p = 0.002) and the TLR3 Leu412Phe CC genotype (OR=2.02, 95%CI=1.01-4.05, p = 0.046) were independently associated with severe HCV recurrence.
|
27101936 |
2016 |
|
Lichen Planus, Oral
|
|
0.010 |
GeneticVariation
|
BEFREE |
No association with OLP risk was observed for the polymorphisms studied in TLR2, TLR4 and CD14 genes or for the rs3775291 polymorphism of the TLR3 gene.
|
24028589 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
No associations were found between rs5744168 (TLR5), rs4986791 (TLR4), rs4986790 (TLR4), and rs3775291 (TLR3) polymorphisms and SLE susceptibility.
|
26762473 |
2016 |
|
Hepatitis C
|
|
0.070 |
GeneticVariation
|
BEFREE |
Our study shows the first evidence that two TLR3 polymorphisms (rs3775291 and rs13126816) seem to be related to the HCV therapy response in HCV/HIV coinfected patients.
|
25766991 |
2015 |
|
Bronchiolitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
|
Pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015).
|
25423559 |
2015 |