|
Japanese Encephalitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A significantly higher frequency of Leu412Phe polymorphism was noted in JE patients as compared with healthy controls [mutant (TT) genotype, P-value=0.019; mutant (TT)+heterozygous (CT) genotype, P-value=0.013].
|
26298326 |
2015 |
|
Meningitis, Bacterial
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated whether bacterial meningitis (BM) in children was associated with gene polymorphisms in TLR2 (rs3804099), TLR3 (rs3775291 and rs3775290) and TLR9 (rs352139 and rs352140).
|
28202935 |
2017 |
|
Wheezing
|
|
0.010 |
GeneticVariation
|
BEFREE |
Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
|
22549436 |
2012 |
|
Malignant neoplasm of mouth
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P = 0.036) compared to wild-type.
|
23796347 |
2014 |
|
Herpes Labialis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Furthermore, the TLR3 L412F genetic polymorphism was found to reduce NK cell TLR3-responsiveness and is associated with susceptibility to recurrent HL.
|
22537752 |
2012 |
|
Asthma
|
|
0.010 |
GeneticVariation
|
BEFREE |
We evaluated whether post-bronchiolitis asthma was associated with polymorphisms in the TLR3 rs3775291, TLR4 rs4986790, TLR7 rs179008, TLR8 rs2407992, TLR9 rs187084, and TLR10 rs4129009 genes.
|
28592890 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Among the 178 SNPs, 24 were significantly associated with NSCLC prognosis in different genetic models and four of them were remained in the final predictive model after multivariate stepwise Cox regression, including IL-5R rs11713419 (5'-untranslated region, 5'-UTR) (P = 0.001), IL23R rs6682925 (5'-flanking region, 5'-FR) (P = 0.017), TLR1 rs5743551 (5'-FR) (P = 0.02) and TLR3 rs3775291 (Leu412Phe) (P = 0.01).
|
21412764 |
2012 |
|
Sarcoidosis, Pulmonary
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study identifies defective TLR3 function as a previously unidentified factor in persistent clinical disease in pulmonary sarcoidosis and reveals TLR3 L412F as a candidate biomarker.
|
29237089 |
2018 |
|
Idiopathic Pulmonary Fibrosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
TLR3 L412F was also associated with a significantly greater risk of mortality and an accelerated decline in FVC in patients with IPF.
|
24070541 |
2013 |
|
Hepatitis C, Chronic
|
|
0.010 |
GeneticVariation
|
BEFREE |
In a multivariate analysis, TLR3 L412F was significantly associated with chronic hepatitis C (odds ratio: 1.73, 95% confidence interval [CI]: 1.13-2.65, P = 0.01).
|
23240626 |
2013 |
|
Pancreatitis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015).
|
25423559 |
2015 |
|
Complete atrioventricular block
|
|
0.010 |
GeneticVariation
|
BEFREE |
These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF.
|
23076446 |
2013 |
|
Bacterial Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
Recently we have shown an association of a TLR3 receptor variant, L412F, to susceptibility to chronic candidiasis, recurrent viral and bacterial infections and autoimmunity.
|
22024499 |
2012 |
|
Multiple Sclerosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
There appears to be a possible association between the TLR3 missense mutation rs3775291 and multiple sclerosis, which might be attributed to changes in the TLR3 functional properties.
|
31177052 |
2019 |
|
Malignant neoplasm of breast
|
|
0.010 |
GeneticVariation
|
BEFREE |
In this prospective observational study, rs3775291 in TLR3 and rs4833095 in TLR1 were genotyped in 715 patients with primary breast cancer in a Chinese population.
|
26226228 |
2015 |
|
Virus Diseases
|
|
0.010 |
GeneticVariation
|
BEFREE |
Genetic association studies have provided evidence concerning the role of a polymorphism in TLR3 (rs3775291, Leu412Phe) in viral infection susceptibility.
|
22174453 |
2012 |
|
Cytomegalovirus Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
We found an increased frequency of the heterozygous genotype TLR3 L412F in children with HCMV infection compared with uninfected cases.
|
28046022 |
2017 |
|
Polypoidal choroidal vasculopathy
|
|
0.010 |
GeneticVariation
|
BEFREE |
This study indicates that the TLR3 rs3775291 gene polymorphism is not associated with CNV and PCV in Singaporean Chinese patients.
|
21079408 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
|
0.010 |
GeneticVariation
|
BEFREE |
Significant increase in oral cancer risk was observed in individuals with mutated genotype of TLR3 rs3775291 polymorphism (OR = 1.096, P = 0.036) compared to wild-type.
|
23796347 |
2014 |
|
HIV-1 infection
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
Cutaneous Candidiasis
|
|
0.010 |
GeneticVariation
|
BEFREE |
The biological significance of TLR3 variant, L412F, in conferring susceptibility to cutaneous candidiasis, CMV and autoimmunity.
|
22024499 |
2012 |
|
Myocarditis
|
|
0.010 |
GeneticVariation
|
BEFREE |
A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection.
|
23962581 |
2013 |
|
Drug usage
|
|
0.010 |
GeneticVariation
|
BEFREE |
We genotyped rs3775291 in a population of Spanish HIV-1-exposed seronegative (HESN) individuals who remain HIV seronegative despite repeated exposure through i.v. injection drug use (IDU-HESN individuals) as witnessed by their hepatitis C virus seropositivity.
|
22174453 |
2012 |
|
HIV Infections
|
|
0.010 |
GeneticVariation
|
BEFREE |
The TLR3 rs3775291 T allele has a protective effect against HIV infection among HESNs IDUs.
|
23962581 |
2013 |
|
Lupus Erythematosus, Systemic
|
|
0.010 |
GeneticVariation
|
BEFREE |
No associations were found between rs5744168 (TLR5), rs4986791 (TLR4), rs4986790 (TLR4), and rs3775291 (TLR3) polymorphisms and SLE susceptibility.
|
26762473 |
2016 |