rs3775291, TLR3

N. diseases: 30
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.050 GeneticVariation BEFREE Association of toll-like receptor 3 polymorphism rs3775291 with age-related macular degeneration: a systematic review and meta-analysis. 26796995 2017
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.050 GeneticVariation BEFREE The genetic association between a variant in the Toll-like receptor 3 (TLR3) gene (C1234T in mRNA, L412F in protein, Reference SNP Cluster Report rs3775291) and geographic atrophy (GA; also called advanced "dry" age-related macular degeneration) was controversial in previous studies. 21712495 2011
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.050 GeneticVariation BEFREE Even with previously verified samples sets and adequate study powers, the results did not confirm the reported associations of TLR3 rs3775291 and TLR4 rs4986790 with AMD in the three independent samples, individually or combined. 19628747 2009
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.050 GeneticVariation BEFREE Coding SNPs in TLR3 (rs3775291) and TLR7 (rs179008) showed association with AMD in one group (P = 0.01 and P = 0.02, respectively) before correction for multiple testing. 18385087 2008
Age related macular degeneration
CUI: C0242383
Disease: Age related macular degeneration
0.050 GeneticVariation BEFREE We tested for an association between the functional toll-like receptor 3 gene (TLR3) variant rs3775291 (involving the substitution of phenylalanine for leucine at amino acid 412) and age-related macular degeneration in Americans of European descent. 18753640 2008
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE TLR3 rs3775291 was associated with both geographic atrophy (GA) and neovascular AMD (nAMD), with marginally significant pooled-P values. 26796995 2017
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE Toll-like receptor 3 C1234T may protect against geographic atrophy through decreased dsRNA binding capacity. 21712495 2011
Geographic Atrophy
CUI: C1536085
Disease: Geographic Atrophy
0.030 GeneticVariation BEFREE The Phe variant (encoded by the T allele at rs3775291) was associated with protection against geographic atrophy (P=0.005). 18753640 2008
Tick-Borne Encephalitis
CUI: C0014061
Disease: Tick-Borne Encephalitis
0.020 GeneticVariation BEFREE A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. 23962581 2014
Tick-Borne Encephalitis
CUI: C0014061
Disease: Tick-Borne Encephalitis
0.020 GeneticVariation BEFREE Association of single nucleotide polymorphism rs3775291 in the coding region of the TLR3 gene with predisposition to tick-borne encephalitis in a Russian population. 23721942 2013
Breast Carcinoma
CUI: C0678222
Disease: Breast Carcinoma
0.010 GeneticVariation BEFREE A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse. 26226228 2016
Malignant neoplasm of breast
CUI: C0006142
Disease: Malignant neoplasm of breast
0.010 GeneticVariation BEFREE A Prospective Evaluation of the Association between a Single Nucleotide Polymorphism rs3775291 in Toll-Like Receptor 3 and Breast Cancer Relapse. 26226228 2016
Dengue Fever
CUI: C0011311
Disease: Dengue Fever
0.010 GeneticVariation BEFREE Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. 25446400 2015
Severe Dengue
CUI: C0019100
Disease: Severe Dengue
0.010 GeneticVariation BEFREE Results revealed significantly lower frequency of TLR3 rs3775291 T allele [DHF vs. DF P = 0.015 odds ratio (OR) with 95% confidence interval (CI) 0.390 (0.160–0.880); DHF vs. HC P = 0.018 OR with 95% CI 0.410 (0.170–0.900)] and ‘T’ allele carriers [DHF vs. DF P = 0.008 OR with 95% CI 0.288 (0.115–0.722); DHF vs. HC P = 0.040 OR with 95% CI 0.393 (0.162–0.956)] and higher frequency of TIRAP rs8177374 ‘C/T’ genotype [DHF vs. HC P = 0.020 OR with 95% CI 2.643 (1.167–5.986)] in DHF. 25446400 2015
Pancreatitis
CUI: C0030305
Disease: Pancreatitis
0.010 GeneticVariation BEFREE Regarding severity, CC genotype patients in TLR3 rs3775291 had an increased risk for severe pancreatitis (CC odds ratio [OR], 2.426; P = 0.015). 25423559 2015
HIV Infections
CUI: C0019693
Disease: HIV Infections
0.010 GeneticVariation BEFREE The TLR3 rs3775291 T allele has a protective effect against HIV infection among HESNs IDUs. 23962581 2014
Myocarditis
CUI: C0027059
Disease: Myocarditis
0.010 GeneticVariation BEFREE A polymorphism in TLR3, rs3775291 (Leu412Phe), has been associated with the increased susceptibility to enteroviral myocarditis, protection against tick-borne encephalitis virus and HIV-1 infection. 23962581 2014
Hamman-Rich syndrome
CUI: C0085786
Disease: Hamman-Rich syndrome
0.010 GeneticVariation BEFREE The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. 24070541 2014
Diabetes Mellitus, Insulin-Dependent
0.010 GeneticVariation BEFREE The TLR3 rs3775291 and rs13126816 polymorphisms are associated with risk for T1DM, while the rs5743313 and rs11721827 polymorphisms are associated with age at T1DM diagnosis and poor glycemic control. 24408902 2014
Idiopathic Pulmonary Fibrosis
CUI: C1800706
Disease: Idiopathic Pulmonary Fibrosis
0.010 GeneticVariation BEFREE The Toll-like receptor 3 L412F polymorphism and disease progression in idiopathic pulmonary fibrosis. 24070541 2014
Bronchiolitis
CUI: C0006271
Disease: Bronchiolitis
0.010 GeneticVariation BEFREE Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing. 22549436 2013
Acute-On-Chronic Liver Failure
CUI: C3850141
Disease: Acute-On-Chronic Liver Failure
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Hepatitis B
CUI: C0019163
Disease: Hepatitis B
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013
Hepatitis B, Chronic
CUI: C0524909
Disease: Hepatitis B, Chronic
0.010 GeneticVariation BEFREE Two polymorphisms in the TLR3 gene, A952T and C1234T, were tested by direct sequencing in 452 chronic hepatitis B (CHB) patients and 462 healthy controls. 23076446 2013
Complete atrioventricular block
CUI: C0151517
Disease: Complete atrioventricular block
0.010 GeneticVariation BEFREE These results indicate that TLR3 C1234T polymorphism could be a risk factor for the development of chronic HBV infection, especially the CHB-related ACLF. 23076446 2013