rs377577594, DNMT3A

N. diseases: 7
Disease: Leukemogenesis ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Leukemogenesis
CUI: C0598766
Disease: Leukemogenesis
0.010 GeneticVariation BEFREE Molecularly, both DNMT3A-WT and R882H/C mutants interacted with PRDX2; and R882C/H mutation-induced hypomethylation increased PRDX2 expression which enhanced cell proliferation and growth with impairment of apoptosis, thereby contributing to leukemogenesis. 30245403 2018