|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
GeneticVariation
|
BEFREE |
We took advantage of DNMT3A (R882C) mutation-carrying AML cell strain, that is, OCI-AML3, assessing its migration ability in vitro and in vivo.
|
27724883 |
2016 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Molecular evaluation of DNMT3A and IDH1/2 gene mutation: frequency, distribution pattern and associations with additional molecular markers in normal karyotype Indian acute myeloid leukemia patients.
|
24606448 |
2014 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Three heterozygous mutations (p.R882S, p.R882C and p.R882H) were identified in three of 61 AML patients, whereas none of patients with other hematological disorders harbored any mutation.
|
22744846 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Cancer stem cells: Tracing clones.
|
22898540 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Three heterozygous mutations (p.R882S, p.R882C and p.R882H) were identified in three of 61 AML patients, whereas none of patients with other hematological disorders harbored any mutation.
|
22744846 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
The role of mutations in epigenetic regulators in myeloid malignancies.
|
22898539 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
The role of mutations in epigenetic regulators in myeloid malignancies.
|
22898539 |
2012 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
[Analysis of DNMT3a gene mutations in acute myelogenous leukemia].
|
21518476 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
[Analysis of DNMT3a gene mutations in acute myelogenous leukemia].
|
21518476 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
Impact of genetic features on treatment decisions in AML.
|
22160010 |
2011 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
DNMT3A mutations in acute myeloid leukemia.
|
21067377 |
2010 |
|
Leukemia, Myelocytic, Acute
|
|
0.710 |
CausalMutation
|
CLINVAR |
DNMT3A mutations in acute myeloid leukemia.
|
21067377 |
2010 |
|
MYELODYSPLASTIC SYNDROME
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
|
0.700 |
GeneticVariation
|
CLINVAR |
Identifying recurrent mutations in cancer reveals widespread lineage diversity and mutational specificity.
|
26619011 |
2016 |
|
Leukemia, Myelomonocytic, Chronic
|
|
0.700 |
GeneticVariation
|
UNIPROT |
|
|
|
|
Tatton Brown Rahman syndrome
|
|
0.700 |
CausalMutation
|
CLINVAR |
|
|
|
|
Neoplasm, Residual
|
|
0.010 |
GeneticVariation
|
BEFREE |
We investigated the prognostic impact of minimal residual disease (MRD) monitoring in acute myeloid leukemia patients harboring DNA methyltransferase 3A-R882H/-R882C mutations (DNMT3A<sup>mut</sup>).
|
28643785 |
2018 |
|
Leukemogenesis
|
|
0.010 |
GeneticVariation
|
BEFREE |
Molecularly, both DNMT3A-WT and R882H/C mutants interacted with PRDX2; and R882C/H mutation-induced hypomethylation increased PRDX2 expression which enhanced cell proliferation and growth with impairment of apoptosis, thereby contributing to leukemogenesis.
|
30245403 |
2018 |