rs3824662, GATA3

N. diseases: 11
Disease: Ph-Like Acute Lymphoblastic Leukemia ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Ph-Like Acute Lymphoblastic Leukemia
CUI: C4054188
Disease: Ph-Like Acute Lymphoblastic Leukemia
0.040 GeneticVariation BEFREE <i>GATA3</i> single nucleotide variant rs3824662 shows a strong association with Ph-like ALL (OR = 3.14). 30770347 2019
Ph-Like Acute Lymphoblastic Leukemia
CUI: C4054188
Disease: Ph-Like Acute Lymphoblastic Leukemia
0.040 GeneticVariation BEFREE The germline variant at rs3824662 in GATA3 is a risk locus for Philadelphia-like acute lymphoblastic leukemia (Ph-like ALL), the biological subtype of B-cell precursor (BCP)-ALL defined by a distinct gene expression profile and the presence of specific somatic aberrations including rearrangements of CRLF2. 30859636 2019
Ph-Like Acute Lymphoblastic Leukemia
CUI: C4054188
Disease: Ph-Like Acute Lymphoblastic Leukemia
0.040 GeneticVariation BEFREE The risk allele at rs3824662 was most frequent in Philadelphia chromosome (Ph)-like ALL but also conferred susceptibility to non-Ph-like ALL in AYAs. 25468567 2015
Ph-Like Acute Lymphoblastic Leukemia
CUI: C4054188
Disease: Ph-Like Acute Lymphoblastic Leukemia
0.040 GeneticVariation BEFREE The rs3824662 risk allele was associated with somatic lesions underlying Ph-like ALL (CRLF2 rearrangement, JAK gene mutation and IKZF1 deletion) and with variation in GATA3 expression. 24141364 2013