rs3824662, GATA3

N. diseases: 7
Source: ALL
Disease Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.800 GeneticVariation GWASCAT A genome-wide association study of susceptibility to acute lymphoblastic leukemia in adolescents and young adults. 25468567 2015
Precursor Cell Lymphoblastic Leukemia Lymphoma
0.800 GeneticVariation GWASDB Inherited GATA3 variants are associated with Ph-like childhood acute lymphoblastic leukemia and risk of relapse. 24141364 2014
Precursor B-cell lymphoblastic leukemia
0.700 GeneticVariation GWASCAT Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype. 23996088 2014
Childhood Acute Lymphoblastic Leukemia
0.020 GeneticVariation BEFREE GATA3 rs3824662 gene polymorphism as possible risk factor in a cohort of Egyptian patients with pediatric acute lymphoblastic leukemia and its prognostic impact. 27684731 2018
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.020 GeneticVariation BEFREE To investigate the possible role of GATA3 rs3824662 polymorphism as risk factor for the development of acute lymphoblastic leukemia (ALL) in a cohort of Egyptian children and to evaluate its prognostic role. 27684731 2018
Hyperdiploid B Acute Lymphoblastic Leukemia
0.020 GeneticVariation BEFREE These SNPs are located at CDKN2A (rs3731217) and IKZF1 (rs4132601), genes frequently lost in ALL, and at CEBPE (rs2239633), ARID5B (rs7089424), PIP4K2A (rs10764338), and GATA3 (rs3824662), genes located on chromosomes gained in high-hyperdiploid ALL. 26575185 2016
Hyperdiploid B Acute Lymphoblastic Leukemia
0.020 GeneticVariation BEFREE The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL. 23996088 2014
Childhood Acute Lymphoblastic Leukemia
0.020 GeneticVariation BEFREE In a genome-wide association study (GWAS) of 511 ALL cases and 6,661 non-ALL controls, we identified a susceptibility locus for Ph-like ALL (GATA3, rs3824662; P = 2.17 × 10(-14), odds ratio (OR) = 3.85 for Ph-like ALL versus non-ALL; P = 1.05 × 10(-8), OR = 3.25 for Ph-like ALL versus non-Ph-like ALL), with independent validation. 24141364 2014
Acute lymphocytic leukemia
CUI: C0023449
Disease: Acute lymphocytic leukemia
0.020 GeneticVariation BEFREE The rs10828317 association was shown to be specifically associated with hyperdiploid ALL, whereas the rs3824662-associated risk was confined to nonhyperdiploid non-TEL-AML1 + ALL. 23996088 2014
Adult Acute Lymphocytic Leukemia
CUI: C0751606
Disease: Adult Acute Lymphocytic Leukemia
0.010 GeneticVariation BEFREE To investigate the possible role of GATA3 rs3824662 polymorphism as risk factor for the development of acute lymphoblastic leukemia (ALL) in a cohort of Egyptian children and to evaluate its prognostic role. 27684731 2018
Ph-Like Acute Lymphoblastic Leukemia
0.010 GeneticVariation BEFREE The rs3824662 risk allele was associated with somatic lesions underlying Ph-like ALL (CRLF2 rearrangement, JAK gene mutation and IKZF1 deletion) and with variation in GATA3 expression. 24141364 2014