rs3846662, HMGCR

N. diseases: 12
Disease: Alzheimer's Disease ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.050 GeneticVariation BEFREE Using logistic regressions and survival curves, we found a significant association between AD and rs3846662, with a stronger association in individuals who carry the APOE e4 allele, supporting previously published work. 30975575 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.050 GeneticVariation BEFREE Previous reports identified that HMGCR rs3846662 polymorphism is associated with biosynthesis of cholesterol in AD pathology. 27009838 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.050 GeneticVariation BEFREE Effects of rs3846662 Variants on HMGCR mRNA and Protein Levels and on Markers of Alzheimer's Disease Pathology. 26541602 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.050 GeneticVariation BEFREE The results of our study indicated that HMGCR (rs3846662) plays a vital role in AD pathology mainly by influencing brain structure and glucose metabolism during AD progression. 26950278 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.050 GeneticVariation BEFREE In conclusion, HMGCR rs3846662 acts as a potent genetic modifier for AD risk, age of onset and conversion. 25023145 2015