rs3851179, None

N. diseases: 15
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD. 25169757 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population. 23650005 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship. 30039188 2018
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals. 20697030 2010
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT). 28316001 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein. 24618820 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD. 28073596 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). 24578178 2015
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially. 27048444 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population". 26972434 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD. 26611835 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. 23572399 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASDB These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations. 25452228 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE rs3851179 and rs541458 appear to be associated with decreased AD risk. 31385771 2019
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASCAT These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOEε4-negative subgroup. 23040034 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE There was no association observed with AD at both rs11136000 CLU (p=0.25) and rs3851179 PICALM (p=0.54). 28558900 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor. 28549650 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively). 21726919 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE We detected a significant association of the MTHFR rs1801133 and PICALM rs3851179 polymorphisms with AD. 25359311 2015
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians. 20951388 2011