rs3851179, None

N. diseases: 15
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). 22015308 2012
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia. 27023435 2017
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. 20554627 2010
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118 2015
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects. 22402018 2012
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage. 23643458 2014
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179). 21321396 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD. 20739100 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk. 24670887 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD. 25169757 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE We investigated the influence of the rs6656401 single nucleotide polymorphisms (SNP) of the CR1 gene, the rs3851179 SNP of the PICALM gene, and the rs11136000 SNP of the CLU gene on risk of AD in a Polish population. 23650005 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship. 30039188 2018
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Unadjusted, CLU (odds ratio [OR], 0.91; 95% confidence interval [CI], 0.85-0.96 for single-nucleotide polymorphism [SNP] rs11136000), CR1 (OR, 1.14; 95% CI, 1.07-1.22; SNP rs3818361), and PICALM (OR, 0.89; 95% CI, 0.84-0.94, SNP rs3851179) were associated with AD in white individuals. 20697030 2010
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT). 28316001 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein. 24618820 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The PICALM rs3851179 A allele is thought to have a protective effect, whereas the G allele appears to confer risk for AD. 28073596 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). 24578178 2015
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The sensitivity analysis indicates that the association between rs3851179 and AD did </span>not vary substantially. 27048444 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Re: "PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer's Disease in an Asian Population". 26972434 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The allele T of rs38</span>51179 in PICALM was associated with a 13 % increase in the risk of AD. 26611835 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. 23572399 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASDB These associations were replicated in stage 2 (2,023 cases and 2,340 controls), producing compelling evidence for association with Alzheimer's disease in the combined dataset (rs11136000, P = 8.5 x 10(-10), odds ratio = 0.86; rs3851179, P = 1.3 x 10(-9), odds ratio = 0.86). 19734902 2009
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE The association between rs3851179 (PICALM), rs744373 (BIN1), and AD was further confirmed by meta-analysis of Asian populations. 25452228 2016