rs3851179, None

N. diseases: 15
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Memory impairment
CUI: C0233794
Disease: Memory impairment
0.010 GeneticVariation BEFREE There was an effect of the APOE-PICALM (rs3851179) interactions on reduced CMRgl in regions of vDMN (P < .001), and on memory deficits (F<sub>3,93</sub> =5.568, P = .020). 29883038 2019
Gestational Diabetes
CUI: C0085207
Disease: Gestational Diabetes
0.010 GeneticVariation BEFREE This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT. 28316001 2017
Diabetes Mellitus, Non-Insulin-Dependent
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
0.010 GeneticVariation BEFREE The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism-gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT). 28316001 2017
Impaired glucose tolerance
CUI: C0271650
Disease: Impaired glucose tolerance
0.010 GeneticVariation BEFREE This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT. 28316001 2017
PARKINSON DISEASE, LATE-ONSET
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
0.010 GeneticVariation BEFREE More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk. 28567584 2017
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.010 GeneticVariation BEFREE Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD. 26889634 2016
Familial lichen amyloidosis
CUI: C0268398
Disease: Familial lichen amyloidosis
0.010 GeneticVariation BEFREE 63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84). 24670887 2014
Obesity
CUI: C0028754
Disease: Obesity
0.010 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
Schizophrenia
CUI: C0036341
Disease: Schizophrenia
0.010 GeneticVariation BEFREE Polymorphisms rs11136000 and rs3851179 were analyzed among 184 Chinese patients with schizophrenia and 162 healthy controls. 20738160 2010
Mild cognitive disorder
CUI: C1270972
Disease: Mild cognitive disorder
0.020 GeneticVariation BEFREE The PICALM rs3851179 polymorphism significantly affects the DMN network in MCI. 28549650 2017
Mild cognitive disorder
CUI: C1270972
Disease: Mild cognitive disorder
0.020 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118 2015
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.030 GeneticVariation BEFREE Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD. 26889634 2016
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.030 GeneticVariation BEFREE Our results do not provide evidence that the PICALM rs3851179 polymorphism increase susc</span>eptibility of PD, in the Greek population. 22715855 2012
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.030 GeneticVariation BEFREE The two other SNPs, rs6656401 from CR1, and rs3851179 from PICALM region were not associated with PD (p>0.05). 21912625 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia. 27023435 2017
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118 2015
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage. 23643458 2014
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk. 24670887 2014
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). 22015308 2012
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects. 22402018 2012
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179). 21321396 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD. 20739100 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD. 20554627 2010
Prion Diseases
CUI: C0162534
Disease: Prion Diseases
0.700 GeneticVariation GWASDB Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. 22210626 2012
Autoantibody measurement
CUI: C1272321
Disease: Autoantibody measurement
0.700 GeneticVariation GWASDB Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009