rs3851179, None

N. diseases: 15
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
Obesity
CUI: C0028754
Disease: Obesity
0.010 GeneticVariation BEFREE (2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI  = 4.03 × 10(-05), pBMI corr  = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI  = 0.002, rs2075650 at TOMM40/APOE, pBMI  = 0.024, rs3865444 at CD33, pBMI  = 0.024). 24788522 2014
Familial lichen amyloidosis
CUI: C0268398
Disease: Familial lichen amyloidosis
0.010 GeneticVariation BEFREE 63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84). 24670887 2014
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE rs3851179 and rs541458 appear to be associated with decreased AD risk. 31385771 2019
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia. 27023435 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians. 20951388 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation GWASDB Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. 21460841 2011
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD. 25169757 2014
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013). 22015308 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively). 21726919 2011
Autoantibody measurement
CUI: C1272321
Disease: Autoantibody measurement
0.700 GeneticVariation GWASDB Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. 19734900 2009
Prion Diseases
CUI: C0162534
Disease: Prion Diseases
0.700 GeneticVariation GWASDB Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP. 22210626 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein. 24618820 2014
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD. 20739100 2011
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects. 22402018 2012
PARKINSON DISEASE, LATE-ONSET
CUI: C3160718
Disease: PARKINSON DISEASE, LATE-ONSET
0.010 GeneticVariation BEFREE More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk. 28567584 2017
Impaired cognition
CUI: C0338656
Disease: Impaired cognition
0.010 GeneticVariation BEFREE Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD. 26889634 2016
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.030 GeneticVariation BEFREE Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD. 26889634 2016
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship. 30039188 2018
Parkinson Disease
CUI: C0030567
Disease: Parkinson Disease
0.030 GeneticVariation BEFREE Our results do not provide evidence that the PICALM rs3851179 polymorphism increase susc</span>eptibility of PD, in the Greek population. 22715855 2012
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. 23572399 2013
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor. 28549650 2017
Alzheimer's Disease
CUI: C0002395
Disease: Alzheimer's Disease
0.900 GeneticVariation BEFREE PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD). 24578178 2015
Mild cognitive disorder
CUI: C1270972
Disease: Mild cognitive disorder
0.020 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118 2015
Alzheimer Disease, Late Onset
CUI: C0494463
Disease: Alzheimer Disease, Late Onset
0.090 GeneticVariation BEFREE PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD. 25189118 2015