Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
Obesity
|
|
0.010 |
GeneticVariation
|
BEFREE |
(2) Four additional AD risk SNPs were nominally associated with obesity (rs17125944 at FERMT2, pBMI = 4.03 × 10(-05), pBMI corr = 2.50 × 10(-03) ; rs3851179 at PICALM; pBMI = 0.002, rs2075650 at TOMM40/APOE, pBMI = 0.024, rs3865444 at CD33, pBMI = 0.024).
|
24788522 |
2014 |
Familial lichen amyloidosis
|
|
0.010 |
GeneticVariation
|
BEFREE |
63) associated nominally significantly with posterior AD, and rs3851179 at the PICALM locus had significant association with PCA (p = 0.0003, OR = 2.84).
|
24670887 |
2014 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
rs3851179 and rs541458 appear to be associated with decreased AD risk.
|
31385771 |
2019 |
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
A recent genome-wide study (GWAS) identified a single nucleotide polymorphism (SNP) rs3851179 in the 5' to the PICALM gene strongly associated with Alzheimer's disease (AD) in Caucasians.
|
20951388 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
GWASDB |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Conditional on rs3851179, rs588076 was not associated with AD risk, suggesting that D18-19 PICALM is not critical in AD.
|
25169757 |
2014 |
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013).
|
22015308 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Gene-brain structure associations of 3 recently discovered risk genes for Alzheimer's disease, CLU (rs11136000C>T), CR1 (rs6656401G>A), and PICALM (rs3851179G>A), were investigated in 2 independent cohorts of young healthy adults (n = 430 and n = 492, respectively).
|
21726919 |
2011 |
Autoantibody measurement
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
|
19734900 |
2009 |
Prion Diseases
|
|
0.700 |
GeneticVariation
|
GWASDB |
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.
|
22210626 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Here, we evaluated the association between the AD-associated polymorphism rs3851179 near PICALM, which encodes a clathrin-coated pit accessory protein.
|
24618820 |
2014 |
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD.
|
20739100 |
2011 |
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
PARKINSON DISEASE, LATE-ONSET
|
|
0.010 |
GeneticVariation
|
BEFREE |
More genetic studies using large-sized and well-defined matched samples of AD and PD patients from mixed populations as well as functional correlation analysis are urgently needed to clarify the role of rs3851179 in the AD/PD risk.
|
28567584 |
2017 |
Impaired cognition
|
|
0.010 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our finding suggests that PICALM rs3851179 could contribute to cognitive impairment in older patients with PD.
|
26889634 |
2016 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our meta-analysis thus suggested that the PICALM rs3851179 polymorphism was associated with AD;</span> the APOE ε4 status did not influence the relationship.
|
30039188 |
2018 |
Parkinson Disease
|
|
0.030 |
GeneticVariation
|
BEFREE |
Our results do not provide evidence that the PICALM rs3851179 polymorphism increase susc</span>eptibility of PD, in the Greek population.
|
22715855 |
2012 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods.
|
23572399 |
2013 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
Phosphatidylinositol-binding clathrin assembly protein (PICALM) (rs3851179) has been associated with AD; in particular, the A allele may serve a protective role, while the G allele serves as a strong genetic risk factor.
|
28549650 |
2017 |
Alzheimer's Disease
|
|
0.900 |
GeneticVariation
|
BEFREE |
PICALM rs3851179 and CLU rs11136000 have been recently associated with Alzheimer's disease (AD).
|
24578178 |
2015 |
Mild cognitive disorder
|
|
0.020 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |