|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
A case-control study was conducted in 362 individuals (181 LOADs and 181 controls) to determine the association of single-nucleotide polymorphisms in APOE (e2, e3, and e4), TOMM40 (rs2075650), CR1 (rs665640), PVRL2 (rs6859), SORL1 (rs11218304), PICALM (rs3851179), and GWA_14q32.13 (rs11622883) with LOAD in a sample from Colombia.
|
27023435 |
2017 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
PICALM-rs3851179-G had an unexpected protective effect on incident MCI/LOAD.
|
25189118 |
2015 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
Single nucleotide polymorphisms at the LOAD risk loci CLU (rs11136000), CR1 (rs6656401, rs3818361), and PICALM (rs3851179) were genotyped and tested for association with Logical Memory immediate recall, Logical Memory delayed recall, Logical Memory percent retention, Visual Reproduction immediate recall, Visual Reproduction delayed recall, and Visual Reproduction percent retention scores from the Wechsler Memory Scale-Revised using multivariable linear regression analysis, adjusting for age at exam, sex, education, and apolipoprotein E ε4 dosage.
|
23643458 |
2014 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
The effects for all SNPs, except rs3851179, were consistent with those for LOAD risk.
|
24670887 |
2014 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
For PICALM, LOAD association was found only in the APOE ε4 (-) subgroup (rs3851179 adjusted allelic p = 0.028; adjusted genotypic p = 0.013).
|
22015308 |
2012 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
In order to evaluate association with these genome-wide association study-identified genes and to isolate the variants contributing to the pathogenesis of LOAD, we genotyped the top single nucleotide polymorphisms (SNPs), rs11136000 (CLU), rs3818361 (CR1), and rs3851179 (PICALM), and sequenced the entire coding regions of these genes in our cohort of 342 LOAD patients and 277 control subjects.
|
22402018 |
2012 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
We also tested for epistatic interaction between these variants and APOE ε4 as well as with the previously replicated LOAD GWAS genes (CLU: rs11136000, CR1: rs3818361, and PICALM: rs3851179).
|
21321396 |
2011 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
In addition, one variation, rs3851179, in the phosphatidylinositol binding clathrin assembly protein (PICALM) gene and one variation, rs6656401, in the complement component (3b/4b) receptor 1 (CR) gene were associated with AD.
|
20739100 |
2011 |
|
Alzheimer Disease, Late Onset
|
|
0.090 |
GeneticVariation
|
BEFREE |
The most significant single-nucleotide polymorphisms in CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179) were tested for allelic association with LOAD.
|
20554627 |
2010 |