rs387906656, MYH6

N. diseases: 6
Disease: Sick Sinus Syndrome ×
Source: ALL
Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE We show that the lifetime risk of being diagnosed with sick sinus syndrome is around 6% for non-carriers of c.2161C>T but is approximately 50% for carriers of the c.2161C>T variant. 21378987 2011
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE Moreover, a rare MYH6 variant, R721W, predisposing susceptibility to sick sinus syndrome has been identified. 25717017 2015
Sick Sinus Syndrome
CUI: C0037052
Disease: Sick Sinus Syndrome
0.030 GeneticVariation BEFREE We have previously reported broad effects of p.Arg721Trp on cardiac electrical function and strong association with sick sinus syndrome and atrial fibrillation. 29590334 2018